КФУ. Карточка публикации. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

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ANTIBACTERIAL EFFECTS OF QUATERNARY BIS-PHOSPHONIUM AND AMMONIUM SALTS OF PYRIDOXINE ON STAPHYLOCOCCUS AUREUS CELLS: A SINGLE BASE HITTING TWO DISTINCT TARGETS?

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Евтюгин Владимир Геннадьевич, автор

Каюмов Айрат Рашитович, автор

Никитина Елена Владимировна, автор

Пугачев Михаил Владимирович, автор

Федосимова Светлана Владимировна, автор

Штырлин Юрий Григорьевич, автор

Другие авторы

Богачев Михаил Игоревич, автор

Авторы, аспиранты КФУ

Кузнецова Светлана Владимировна, автор

Библиографическое описание на языке оригинала

Nikitina E.V. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets? / Nikitina E.V., Zeldi M. I., Pugachev M.V., Sapozhnikov S.V., Shtyrlin N.V., Kuznetsova S.V., Evtygin V.E., Bogachev M.I., Kayumov A.R., Shtyrlin Y.G. // World Journal of Microbiology and Biotechnology. - 2016. - V.32, Is.1.

Аннотация

We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca2+ ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca2+ ions can successfully impede the membrane Ca2+ ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no e

Ключевые слова

Quaternary phosphonium salts, Quaternary ammonium salts, Pyridoxine, Antibacterial activity, Fluorescent microscopy

Название журнала

WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

URL

http://link.springer.com/article/10.1007/s11274-015-1969-0

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https://repository.kpfu.ru/?p_id=124017

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Евтюгин Владимир Геннадьевич	ru_RU
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.contributor.author	Никитина Елена Владимировна	ru_RU
dc.contributor.author	Пугачев Михаил Владимирович	ru_RU
dc.contributor.author	Федосимова Светлана Владимировна	ru_RU
dc.contributor.author	Штырлин Юрий Григорьевич	ru_RU
dc.contributor.author	Богачев Михаил Игоревич	ru_RU
dc.contributor.author	Кузнецова Светлана Владимировна	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Nikitina E.V. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets? / Nikitina E.V., Zeldi M. I., Pugachev M.V., Sapozhnikov S.V., Shtyrlin N.V., Kuznetsova S.V., Evtygin V.E., Bogachev M.I., Kayumov A.R., Shtyrlin Y.G. // World Journal of Microbiology and Biotechnology. - 2016. - V.32, Is.1.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=124017	ru_RU
dc.description.abstract	WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY	ru_RU
dc.description.abstract	We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca2+ ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca2+ ions can successfully impede the membrane Ca2+ ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no e	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Quaternary phosphonium salts	ru_RU
dc.subject	Quaternary ammonium salts	ru_RU
dc.subject	Pyridoxine	ru_RU
dc.subject	Antibacterial activity	ru_RU
dc.subject	Fluorescent microscopy	ru_RU
dc.title	Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU