| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Абдуллин Тимур Илдарович, автор
Салихова Талия Илшатовна, автор
Сираева Зульфира Юнысовна, автор
|
| Библиографическое описание на языке оригинала |
Siraeva Z., Đặng T., Yergeshov A., Salikhova T., Lopukhov L., Abdullin T. Evaluation of skin irritation in rats using simultaneous laser
Doppler flowmetry and oxygenation monitoring. BioNanoScience. 2016. BioNanoScience, 6(4): 384-387. DOI 10.1007/s12668-016-0242-9 |
| Аннотация |
The possibility of assessment of skin irritation
in rats with the use of simultaneous laser Doppler
flowmetry (LDF) and oxygenation monitoring was investigated.
The study was designed according to ISO 10993-
10 using formaldehyde as a model irritant. 4-Hour application
of 1 % formaldehyde induced significant local
increase in skin microcirculation for the first 2 days by
a factor of up to 2.4, whereas tissue oxygenation increased
in much lower extent. The microcirculation was
significantly inhibited by 10 % formaldehyde following
treatment and then it gradually increased for 24 and 48 h
of recovery period. The results correlated with visual
evaluation of skin edema and erythema in treated zones.
LDF/oxygenation signals provide early information on
skin irritation and damage in rat model. The technique
is valuable for preclinical/toxicological studies of chemical
substances and medical materials. |
| Ключевые слова |
Doppler flowmetry, microcirculation, tissue oxygenation, skin irritation, formaldehyde |
| Название журнала |
BioNanoScience
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=137444 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абдуллин Тимур Илдарович |
ru_RU |
| dc.contributor.author |
Салихова Талия Илшатовна |
ru_RU |
| dc.contributor.author |
Сираева Зульфира Юнысовна |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Siraeva Z., Đặng T., Yergeshov A., Salikhova T., Lopukhov L., Abdullin T. Evaluation of skin irritation in rats using simultaneous laser
Doppler flowmetry and oxygenation monitoring. BioNanoScience. 2016. BioNanoScience, 6(4): 384-387. DOI 10.1007/s12668-016-0242-9 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=137444 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
The possibility of assessment of skin irritation
in rats with the use of simultaneous laser Doppler
flowmetry (LDF) and oxygenation monitoring was investigated.
The study was designed according to ISO 10993-
10 using formaldehyde as a model irritant. 4-Hour application
of 1 % formaldehyde induced significant local
increase in skin microcirculation for the first 2 days by
a factor of up to 2.4, whereas tissue oxygenation increased
in much lower extent. The microcirculation was
significantly inhibited by 10 % formaldehyde following
treatment and then it gradually increased for 24 and 48 h
of recovery period. The results correlated with visual
evaluation of skin edema and erythema in treated zones.
LDF/oxygenation signals provide early information on
skin irritation and damage in rat model. The technique
is valuable for preclinical/toxicological studies of chemical
substances and medical materials. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Doppler flowmetry |
ru_RU |
| dc.subject |
microcirculation |
ru_RU |
| dc.subject |
tissue oxygenation |
ru_RU |
| dc.subject |
skin irritation |
ru_RU |
| dc.subject |
formaldehyde |
ru_RU |
| dc.title |
Evaluation of skin irritation in rats using simultaneous laser
Doppler flowmetry and oxygenation monitoring |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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