КФУ. Карточка публикации. Exogenous Bacillus pumilus RNase (binase) suppresses the reproduction of reovirus serotype 1

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EXOGENOUS BACILLUS PUMILUS RNASE (BINASE) SUPPRESSES THE REPRODUCTION OF REOVIRUS SEROTYPE 1

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Зеленихин Павел Валерьевич, автор

Ильинская Ольга Николаевна, автор

Колпаков Алексей Иванович, автор

Шах Махмуд Раихан , автор

Другие авторы

Эфимова Марина Анатольевна, автор

Авторы, студенты КФУ

Сабирова Миляуша Ильсуровна, автор

Библиографическое описание на языке оригинала

Efimova M. A. Exogenous Bacillus pumilus RNase (binase) suppresses the reproduction of reovirus serotype 1 / M. A. Efimova, R. Shah Mahmud, P. V. Zelenikhin, M. I. Sabirova, A. I. Kolpakov, O. N. Ilinskaya // Molecular Biology. - 2017. - V. 51, I. 1. - P. 96–101.

Аннотация

The experimental study identified the antiviral activity of Bacillus pumilus RNase (binase) against the reovirus of serotype 1/strain Lang. For the first time, it has been found that 50 μg/mL of binase effectively reduced the hemagglutinin and cytocidal activity of reovirus in Vero cell line. The preincubation of the enzyme with reovirus before infection of the cells inhibited the viral replication. To determine the stagedependent effect of reovirus reproduction upon binase inhibition, the infected cells were treated with binase or RNase A at different phases of the infectious cycle. The treatment of virus-infected cells has revealed that both enzymes have a maximal antiviral effect on the reovirus propagation during early phases of the reovirus reproduction cycle, with binase being more effective than RNase A. It has been hypothesized that the combined action of the oncolytic reovirus and binase is promising for the elimination of tumor cells carrying mutated RAS gene.

Ключевые слова

binase, Bacillus pumilus, RNase, reovirus, antiviral agent

Название журнала

Molecular Biology

URL

http://rd.springer.com/article/10.1134/S0026893316060042

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https://repository.kpfu.ru/?p_id=152171

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зеленихин Павел Валерьевич	ru_RU
dc.contributor.author	Ильинская Ольга Николаевна	ru_RU
dc.contributor.author	Колпаков Алексей Иванович	ru_RU
dc.contributor.author	Шах Махмуд Раихан	ru_RU
dc.contributor.author	Эфимова Марина Анатольевна	ru_RU
dc.contributor.author	Сабирова Миляуша Ильсуровна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Efimova M. A. Exogenous Bacillus pumilus RNase (binase) suppresses the reproduction of reovirus serotype 1 / M. A. Efimova, R. Shah Mahmud, P. V. Zelenikhin, M. I. Sabirova, A. I. Kolpakov, O. N. Ilinskaya // Molecular Biology. - 2017. - V. 51, I. 1. - P. 96–101.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=152171	ru_RU
dc.description.abstract	Molecular Biology	ru_RU
dc.description.abstract	The experimental study identified the antiviral activity of Bacillus pumilus RNase (binase) against the reovirus of serotype 1/strain Lang. For the first time, it has been found that 50 μg/mL of binase effectively reduced the hemagglutinin and cytocidal activity of reovirus in Vero cell line. The preincubation of the enzyme with reovirus before infection of the cells inhibited the viral replication. To determine the stagedependent effect of reovirus reproduction upon binase inhibition, the infected cells were treated with binase or RNase A at different phases of the infectious cycle. The treatment of virus-infected cells has revealed that both enzymes have a maximal antiviral effect on the reovirus propagation during early phases of the reovirus reproduction cycle, with binase being more effective than RNase A. It has been hypothesized that the combined action of the oncolytic reovirus and binase is promising for the elimination of tumor cells carrying mutated RAS gene.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	binase	ru_RU
dc.subject	Bacillus pumilus	ru_RU
dc.subject	RNase	ru_RU
dc.subject	reovirus	ru_RU
dc.subject	antiviral agent	ru_RU
dc.title	Exogenous Bacillus pumilus RNase (binase) suppresses the reproduction of reovirus serotype 1	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU