| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2014 |
| Язык | русский |
|
Ильинская Ольга Николаевна, автор
Несмелов Александр Александрович, автор
|
| Библиографическое описание на языке оригинала |
Azat R. Garipov, Alexander A. Nesmelov, Hector A. Cabrera-Fuentes, Olga N. Ilinskaya, Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells, Toxicon, Volume 92, 15 December 2014, Pages 54-59, ISSN 0041-0101, http://dx.doi.org/10.1016/j.toxicon.2014.09.014. |
| Аннотация |
The cytotoxic effects ofBacillus intermediusRNase (binase) towards ovarian cancer cells
(SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1
and HOSE2). Binase decreased viability and induced the selective apoptosis of ovarian cancer
cells. The apoptosis rate was 50% in SKOV3 and 48% in OVCAR5 cells after 24 h of binase treatment (50 mg/ml). Binase-induced apoptosis in these cell lines was accompanied by caspase-3 activation and poly(ADP-ribose) polymerase fragmentation. Normal ovarian epithelial cells were not affected by binase, except for a slight decrease of HOSE2 cell viability and the appearance of traces of activated caspase-3, but not the poly(ADP-ribose) polymerase 85-kDA fragment. Binase did not induce alteration of EZH2 protein expression neither, in tumor nor in normal cells. In conclusion, selective binase-induced cell death and apoptosis may serve as a new treatment option against ovarian cancer progression. |
| Ключевые слова |
Binase
Ovarian cancer
Apoptosis
Caspase-3
PARP
EZH2 |
| Название журнала |
Toxicon
|
| URL |
http://www.sciencedirect.com/science/article/pii/S0041010114003298 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=98323 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Ильинская Ольга Николаевна |
ru_RU |
| dc.contributor.author |
Несмелов Александр Александрович |
ru_RU |
| dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2014 |
ru_RU |
| dc.identifier.citation |
Azat R. Garipov, Alexander A. Nesmelov, Hector A. Cabrera-Fuentes, Olga N. Ilinskaya, Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells, Toxicon, Volume 92, 15 December 2014, Pages 54-59, ISSN 0041-0101, http://dx.doi.org/10.1016/j.toxicon.2014.09.014. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=98323 |
ru_RU |
| dc.description.abstract |
Toxicon |
ru_RU |
| dc.description.abstract |
The cytotoxic effects ofBacillus intermediusRNase (binase) towards ovarian cancer cells
(SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1
and HOSE2). Binase decreased viability and induced the selective apoptosis of ovarian cancer
cells. The apoptosis rate was 50% in SKOV3 and 48% in OVCAR5 cells after 24 h of binase treatment (50 mg/ml). Binase-induced apoptosis in these cell lines was accompanied by caspase-3 activation and poly(ADP-ribose) polymerase fragmentation. Normal ovarian epithelial cells were not affected by binase, except for a slight decrease of HOSE2 cell viability and the appearance of traces of activated caspase-3, but not the poly(ADP-ribose) polymerase 85-kDA fragment. Binase did not induce alteration of EZH2 protein expression neither, in tumor nor in normal cells. In conclusion, selective binase-induced cell death and apoptosis may serve as a new treatment option against ovarian cancer progression. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Bacillus intermedius ribonuclease (BINASE) induces apoptosis
in human ovarian cancer cells |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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