| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2015 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Хабибрахманов Инсаф Илхамович, автор
|
|
Зефиров Андрей Львович, автор
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| Библиографическое описание на языке оригинала |
Zefirov T.L. Age-dependent peculiarities of the rat's heart cholinergic regulation / T.L. Zefirov, N.I. Ziatdinova, I.I. Khabibrakhmanov // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. Volume 101, Issue 2, 1 February 2015, Pages 189-199. |
| Аннотация |
In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior blockade of all three subtypes M-AChR did not prevent inhibitory effect of carbacholin on contractility of the atria and ventricles the animals of all studied age groups. The presence of the positive chronotropic response was found after blockade of M3-cholinoreceptor in 20 weeks-old rats. The absence of cardiac chronotropic response to the blockade of M2-receptor was revealed. In 3, 6, 8 weeks-old rats the selective blockade of M-AChR does not change of the heart chronotrope. At the same time, the effect of the M1- and M2-AChR blockade on myocardial contractility was revealed. |
| Ключевые слова |
Rat, muscarinic cholinoreceptors, heart |
| Название журнала |
Neuroscience and Behavioral Physiology
|
| URL |
https://www.scopus.com/record/display.uri?eid=2-s2.0-84930692171&origin=resultslist&sort=plf-f&src=s&sid=4B8F82B73D39BAD3414E8C2ECB36FCB2.wsnAw8kcdt7IPYLO0V48gA%3a360&sot=autdocs&sdt=autdocs&sl=18&s=AU-ID%2856561820400%29&relpos=1&citeCnt=0&searchTerm= |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=100046 |
| Файлы ресурса | |
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|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Хабибрахманов Инсаф Илхамович |
ru_RU |
| dc.contributor.author |
Зефиров Андрей Львович |
ru_RU |
| dc.date.accessioned |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2015 |
ru_RU |
| dc.identifier.citation |
Zefirov T.L. Age-dependent peculiarities of the rat's heart cholinergic regulation / T.L. Zefirov, N.I. Ziatdinova, I.I. Khabibrakhmanov // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. Volume 101, Issue 2, 1 February 2015, Pages 189-199. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=100046 |
ru_RU |
| dc.description.abstract |
Neuroscience and Behavioral Physiology |
ru_RU |
| dc.description.abstract |
In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior blockade of all three subtypes M-AChR did not prevent inhibitory effect of carbacholin on contractility of the atria and ventricles the animals of all studied age groups. The presence of the positive chronotropic response was found after blockade of M3-cholinoreceptor in 20 weeks-old rats. The absence of cardiac chronotropic response to the blockade of M2-receptor was revealed. In 3, 6, 8 weeks-old rats the selective blockade of M-AChR does not change of the heart chronotrope. At the same time, the effect of the M1- and M2-AChR blockade on myocardial contractility was revealed. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Rat |
ru_RU |
| dc.subject |
muscarinic cholinoreceptors |
ru_RU |
| dc.subject |
heart |
ru_RU |
| dc.title |
Age-dependent peculiarities of the rat's heart cholinergic regulation |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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