КФУ. Карточка публикации. Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

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OXIDATIVE STRESS AND MAXI CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Ситдикова Гузель Фаритовна, автор

Другие авторы

Hermann Anton A, автор

Библиографическое описание на языке оригинала

Anton Hermann 1,*, Guzel F. Sitdikova 2 and Thomas M. Weiger Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels// Biomolecules 2015, 5, 1-x manuscripts; doi:10.3390/biom50x000x

Аннотация

All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.

Ключевые слова

Maxi calcium-activated potassium ion channels; BK channels; KCNMA1; redox mechanisms; oxidation; hypoxia; ischemia

Название журнала

Biomolecules

URL

http://www.mdpi.com/search?q=&journal=biomolecules&volume=&authors=Hermann§ion=&issue=&article_type=&special_issue=&page=&search=Search

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=112261

Файлы ресурса

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biomolecules_86563_final.pdf	0,58	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ситдикова Гузель Фаритовна	ru_RU
dc.contributor.author	Hermann Anton A	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Anton Hermann 1,*, Guzel F. Sitdikova 2 and Thomas M. Weiger Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels// Biomolecules 2015, 5, 1-x manuscripts; doi:10.3390/biom50x000x	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=112261	ru_RU
dc.description.abstract	Biomolecules	ru_RU
dc.description.abstract	All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU