КФУ. Карточка публикации. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis

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CCL27: NOVEL CYTOKINE WITH POTENTIAL ROLE IN PATHOGENESIS OF MULTIPLE SCLEROSIS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Белучи Саверио , автор

Ломбарди Винсент Клиффорд , автор

Мартынова Екатерина Владимировна, автор

Хайбуллина Светлана Францевна, автор

Библиографическое описание на языке оригинала

Khaiboullina S.F. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis / S.F. Khaiboullina, A.R. Gumerova, I.Khafizova, E.V. Martynova, V.C. Lombardi, S. Bellusci, A.A. Rizvanov // BioMed Research International. - Vol. 2015. - 2015. - Article ID 189638. - DOI: 10.1155/2015/189638.

Аннотация

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis.

Ключевые слова

Multiple sclerosis, CCL27

Название журнала

BioMed Research International

URL

http://www.hindawi.com/journals/bmri/2015/189638/

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https://repository.kpfu.ru/?p_id=113218

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Белучи Саверио	ru_RU
dc.contributor.author	Ломбарди Винсент Клиффорд	ru_RU
dc.contributor.author	Мартынова Екатерина Владимировна	ru_RU
dc.contributor.author	Хайбуллина Светлана Францевна	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Khaiboullina S.F. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis / S.F. Khaiboullina, A.R. Gumerova, I.Khafizova, E.V. Martynova, V.C. Lombardi, S. Bellusci, A.A. Rizvanov // BioMed Research International. - Vol. 2015. - 2015. - Article ID 189638. - DOI: 10.1155/2015/189638.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=113218	ru_RU
dc.description.abstract	BioMed Research International	ru_RU
dc.description.abstract	Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Multiple sclerosis	ru_RU
dc.subject	CCL27	ru_RU
dc.title	CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU