| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2014 |
| Язык | английский |
|
Сабируллина Гулия Ильнатовна, автор
Ситдикова Гузель Фаритовна, автор
Шафигуллин Марат Ульфатович, автор
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Зефиров Андрей Львович, автор
Зефиров Руслан Андреевич, автор
|
|
Сабируллина Гулия Ильнатовна, автор
|
| Библиографическое описание на языке оригинала |
M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - т.157. - №3 - 302-306. |
| Аннотация |
We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum
by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels. |
| Ключевые слова |
hydrogen sulfi de; smooth muscle cells; stomach; jejunum; potassium channels |
| Название журнала |
Bulletin of Experimental Biology and Medicine
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| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=120336 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Сабируллина Гулия Ильнатовна |
ru_RU |
| dc.contributor.author |
Ситдикова Гузель Фаритовна |
ru_RU |
| dc.contributor.author |
Шафигуллин Марат Ульфатович |
ru_RU |
| dc.contributor.author |
Зефиров Андрей Львович |
ru_RU |
| dc.contributor.author |
Зефиров Руслан Андреевич |
ru_RU |
| dc.contributor.author |
Сабируллина Гулия Ильнатовна |
ru_RU |
| dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2014 |
ru_RU |
| dc.identifier.citation |
M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - т.157. - №3 - 302-306. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=120336 |
ru_RU |
| dc.description.abstract |
Bulletin of Experimental Biology and Medicine |
ru_RU |
| dc.description.abstract |
We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum
by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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