КФУ. Карточка публикации. Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

STOMACH CANCER: INTERCONNECTION BETWEEN THE REDOX STATE, ACTIVITY OF MMP-2, MMP-9 AND STAGE OF TUMOR GROWTH

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Гафуров Марат Ревгерович, автор

Библиографическое описание на языке оригинала

Burlaka A.P, Ganusevich I.I, Gafurov M.R, Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth//Cancer Microenvironment. - 2016. - Vol.9, Is.1. - P.27-32.

Аннотация

High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the super

Ключевые слова

Reactive oxygen species (ROS), Matrix metalloproteinases, Stomach cancer, Gastric cancer, Electron spin resonance (ESR), Electron paramagnetic resonance (EPR), Metastasis

Название журнала

Cancer Microenvironment

URL

http://link.springer.com/article/10.1007/s12307-016-0182-5

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=129842

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Гафуров Марат Ревгерович	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Burlaka A.P, Ganusevich I.I, Gafurov M.R, Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth//Cancer Microenvironment. - 2016. - Vol.9, Is.1. - P.27-32.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=129842	ru_RU
dc.description.abstract	Cancer Microenvironment	ru_RU
dc.description.abstract	High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the super	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Reactive oxygen species (ROS)	ru_RU
dc.subject	Matrix metalloproteinases	ru_RU
dc.subject	Stomach cancer	ru_RU
dc.subject	Gastric cancer	ru_RU
dc.subject	Electron spin resonance (ESR)	ru_RU
dc.subject	Electron paramagnetic resonance (EPR)	ru_RU
dc.subject	Metastasis	ru_RU
dc.title	Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU