| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2011 |
| Язык | английский |
|
Зиятдинова Гузель Камилевна, автор
|
|
Jan Labuda , автор
|
| Библиографическое описание на языке оригинала |
Ziyatdinova, G. Complex electrochemical and impedimetric evaluation of DNA damage by using DNA biosensor based on a carbon screen-printed electrode / G. Ziyatdinova, J. Labuda // Anal. Methods. - 2011. - V. 3. - No. 12. - P. 2777-2782. |
| Аннотация |
DNA biosensor (DNA/SWCNT-COOH-CHIT/SPCE) composed of dsDNA adsorptive layer on a carboxylated single-walled carbon nanotubes?chitosan composite deposited at a commercial carbon based screen-printed electrode has been prepared and applied to a complex investigation of damage to DNA by the Fenton type cleavage agent (hydroxyl radicals formed in the mixture of Cu2+, H2O2 and
ascorbic acid) and copper(II)?quercetin system in 0.1 M PBS pH 7.0 under aerobic conditions. The dsDNA damage detection is performed by using square-wave voltammetry (SWV), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in 1x10(-7) M thioridazine and 1x10(-3) M
K4[Fe(CN)6]/K3Fe(CN)6 in the 0.1 M phosphate buffer solution, pH 7.0. Initial enhancement of the intrinsic guanine and adenine moieties SWV response indicates opening of the helix structure in the first stage of damage. Decrease in the intercalated thioridazine response confirms damage of the helix structure and deep DNA degradation. |
| Ключевые слова |
Biosensors, DNA damage, Electrochemistry |
| Название журнала |
Analytical Methods
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-82555169343&partnerID=40&md5=2e12dfb4b477d73245f14e4292a3892b |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=134859 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зиятдинова Гузель Камилевна |
ru_RU |
| dc.contributor.author |
Jan Labuda |
ru_RU |
| dc.date.accessioned |
2011-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2011-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2011 |
ru_RU |
| dc.identifier.citation |
Ziyatdinova, G. Complex electrochemical and impedimetric evaluation of DNA damage by using DNA biosensor based on a carbon screen-printed electrode / G. Ziyatdinova, J. Labuda // Anal. Methods. - 2011. - V. 3. - No. 12. - P. 2777-2782. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=134859 |
ru_RU |
| dc.description.abstract |
Analytical Methods |
ru_RU |
| dc.description.abstract |
DNA biosensor (DNA/SWCNT-COOH-CHIT/SPCE) composed of dsDNA adsorptive layer on a carboxylated single-walled carbon nanotubes?chitosan composite deposited at a commercial carbon based screen-printed electrode has been prepared and applied to a complex investigation of damage to DNA by the Fenton type cleavage agent (hydroxyl radicals formed in the mixture of Cu2+, H2O2 and
ascorbic acid) and copper(II)?quercetin system in 0.1 M PBS pH 7.0 under aerobic conditions. The dsDNA damage detection is performed by using square-wave voltammetry (SWV), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in 1x10(-7) M thioridazine and 1x10(-3) M
K4[Fe(CN)6]/K3Fe(CN)6 in the 0.1 M phosphate buffer solution, pH 7.0. Initial enhancement of the intrinsic guanine and adenine moieties SWV response indicates opening of the helix structure in the first stage of damage. Decrease in the intercalated thioridazine response confirms damage of the helix structure and deep DNA degradation. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Biosensors |
ru_RU |
| dc.subject |
DNA damage |
ru_RU |
| dc.subject |
Electrochemistry |
ru_RU |
| dc.title |
Complex electrochemical and impedimetric evaluation of DNA damage by using DNA biosensor based on a carbon screen-printed electrode |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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