| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Курбангалиева Альмира Рафаэловна, автор
Танака Кацунори , автор
|
| Библиографическое описание на языке оригинала |
Ogura A. Visualizing trimming dependence of biodistribution and kinetics with homo- and heterogeneous N-glycoclusters on fluorescent albumin / A. Ogura, T. Tahara, S. Nozaki, K. Morimoto, Y. Kizuka, S. Kitazume, M. Hara, S. Kojima, H. Onoe, A. Kurbangalieva, N. Taniguchi, Y. Watanabe, K. Tanaka // Sci. Rep. – 2016. – V. 6. – Art. № 21797. |
| Аннотация |
A series of N-glycans, each sequentially trimmed from biantennary sialoglycans, were homo- or heterogeneously clustered efficiently on fluorescent albumin using a method that combined strainpromoted alkyne-azide cyclization and 6π-azaelectrocyclization. Noninvasive in vivo kinetics and dissection analysis revealed, for the first time, a glycan-dependent shift from urinary to gall bladder excretion mediated by sequential trimming of non-reducing end sialic acids. N-glycoalbumins that were trimmed further, in particular, GlcNAc- and hybrid biantennary-terminated congeners, were selectively taken up by sinusoidal endothelial and stellate cells in the liver, which are critical for diagnosis and treatment of liver fibrillation. Our glycocluster strategy can not only reveal the previously unexplored extracellular functions of N-glycan trimming, but will be classified as the newly emerging glycoprobes
for diagnostic and therapeutic applications. |
| Ключевые слова |
N-glycan, in vivo molecular imaging |
| Название журнала |
SCIENTIFIC REPORTS
|
| URL |
http://www.nature.com/articles/srep21797 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=135635 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.contributor.author |
Танака Кацунори |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Ogura A. Visualizing trimming dependence of biodistribution and kinetics with homo- and heterogeneous N-glycoclusters on fluorescent albumin / A. Ogura, T. Tahara, S. Nozaki, K. Morimoto, Y. Kizuka, S. Kitazume, M. Hara, S. Kojima, H. Onoe, A. Kurbangalieva, N. Taniguchi, Y. Watanabe, K. Tanaka // Sci. Rep. – 2016. – V. 6. – Art. № 21797. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=135635 |
ru_RU |
| dc.description.abstract |
SCIENTIFIC REPORTS |
ru_RU |
| dc.description.abstract |
A series of N-glycans, each sequentially trimmed from biantennary sialoglycans, were homo- or heterogeneously clustered efficiently on fluorescent albumin using a method that combined strainpromoted alkyne-azide cyclization and 6π-azaelectrocyclization. Noninvasive in vivo kinetics and dissection analysis revealed, for the first time, a glycan-dependent shift from urinary to gall bladder excretion mediated by sequential trimming of non-reducing end sialic acids. N-glycoalbumins that were trimmed further, in particular, GlcNAc- and hybrid biantennary-terminated congeners, were selectively taken up by sinusoidal endothelial and stellate cells in the liver, which are critical for diagnosis and treatment of liver fibrillation. Our glycocluster strategy can not only reveal the previously unexplored extracellular functions of N-glycan trimming, but will be classified as the newly emerging glycoprobes
for diagnostic and therapeutic applications. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
N-glycan |
ru_RU |
| dc.subject |
in vivo molecular imaging |
ru_RU |
| dc.title |
Visualizing trimming dependence of biodistribution and kinetics with homo- and heterogeneous N-glycoclusters on fluorescent albumin |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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