| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2015 |
| Язык | английский |
|
Курбангалиева Альмира Рафаэловна, автор
Сайгитбаталова Елена Шириповна, автор
Танака Кацунори , автор
|
|
Сайгитбаталова Елена Шириповна, автор
|
| Библиографическое описание на языке оригинала |
Tsutsui A. Exclusive formation of imino [4+4] cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators / A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka // Med. Chem. Commun. – 2015. – V. 6. – P. 431–436. |
| Аннотация |
We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]-nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress. |
| Ключевые слова |
acrolein, 2,6,9-triazabicyclo[3.3.1]nonanes, 1,5-diazacyclooctanes, oxidative stress |
| Название журнала |
Medicinal Chemical Communications
|
| URL |
http://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00383g#!divAbstract |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=135638 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.contributor.author |
Сайгитбаталова Елена Шириповна |
ru_RU |
| dc.contributor.author |
Танака Кацунори |
ru_RU |
| dc.contributor.author |
Сайгитбаталова Елена Шириповна |
ru_RU |
| dc.date.accessioned |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2015 |
ru_RU |
| dc.identifier.citation |
Tsutsui A. Exclusive formation of imino [4+4] cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators / A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka // Med. Chem. Commun. – 2015. – V. 6. – P. 431–436. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=135638 |
ru_RU |
| dc.description.abstract |
Medicinal Chemical Communications |
ru_RU |
| dc.description.abstract |
We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]-nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
acrolein |
ru_RU |
| dc.subject |
2 |
ru_RU |
| dc.subject |
6 |
ru_RU |
| dc.subject |
9-triazabicyclo[3.3.1]nonanes |
ru_RU |
| dc.subject |
1 |
ru_RU |
| dc.subject |
5-diazacyclooctanes |
ru_RU |
| dc.subject |
oxidative stress |
ru_RU |
| dc.title |
Exclusive formation of imino[4+4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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