| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Абдуллин Тимур Илдарович, автор
Гумерова Дилара Радифовна, автор
Ишкаева Резеда Анасовна, автор
Камалов Марат Ильясович, автор
Низамов Ильяс Саидович, автор
Салахиева Диана Витальевна, автор
|
|
Nemeth, Szilagyi Csaba, Andras , автор
|
| Библиографическое описание на языке оригинала |
Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight. D.V. Salakhieva, D.R. Gumerova, R.A. Akhmadishina, M.I. Kamalov, I.S. Nizamov, C. Nemeth, A. Szilágyi, T. I. Abdullin // BioNanoSci. (2016). doi:10.1007/s12668-016-0230-0. |
| Аннотация |
Effect of poly(succinimide) (PSI) and poly(aspartic acid) (PASP) on free radical reactions and cell viability was assessed. Molecular weight (MW) of PASPs was determined by static light scattering technique, and found as 3.9 and 8.3 kDa. Among PSIs and PASPs only poly(aspartic acid) with higher MW was found to inhibit formation of hydroxyl-radical in Fenton's reaction, although each polymers studied were not able to eliminate diphenylpicrylhydrazyl radical. PASPs were almost non-toxic for 3T3 fibroblasts and PC-3 cells (IC50 >> 3 mg/mL), whereas PSIs diminished cell viability with different IC50 values depending on cell type and polymer MW. Our preliminary data indicate the MW dependence of bioactivity of L aspartic acid-derived polymers designed as drug carriers and biocompatible materials. |
| Ключевые слова |
Poly(succinimide); poly(aspartic acid); molecular weight; free radicals; cytotoxicity |
| Название журнала |
BioNanoScience
|
| URL |
http://doi:10.1007/s12668-016-0230-0 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=139049 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абдуллин Тимур Илдарович |
ru_RU |
| dc.contributor.author |
Гумерова Дилара Радифовна |
ru_RU |
| dc.contributor.author |
Ишкаева Резеда Анасовна |
ru_RU |
| dc.contributor.author |
Камалов Марат Ильясович |
ru_RU |
| dc.contributor.author |
Низамов Ильяс Саидович |
ru_RU |
| dc.contributor.author |
Салахиева Диана Витальевна |
ru_RU |
| dc.contributor.author |
Nemeth, Szilagyi Csaba, Andras |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight. D.V. Salakhieva, D.R. Gumerova, R.A. Akhmadishina, M.I. Kamalov, I.S. Nizamov, C. Nemeth, A. Szilágyi, T. I. Abdullin // BioNanoSci. (2016). doi:10.1007/s12668-016-0230-0. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=139049 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
Effect of poly(succinimide) (PSI) and poly(aspartic acid) (PASP) on free radical reactions and cell viability was assessed. Molecular weight (MW) of PASPs was determined by static light scattering technique, and found as 3.9 and 8.3 kDa. Among PSIs and PASPs only poly(aspartic acid) with higher MW was found to inhibit formation of hydroxyl-radical in Fenton's reaction, although each polymers studied were not able to eliminate diphenylpicrylhydrazyl radical. PASPs were almost non-toxic for 3T3 fibroblasts and PC-3 cells (IC50 >> 3 mg/mL), whereas PSIs diminished cell viability with different IC50 values depending on cell type and polymer MW. Our preliminary data indicate the MW dependence of bioactivity of L aspartic acid-derived polymers designed as drug carriers and biocompatible materials. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Anti-radical and cytotoxic activity of polysuccinimide and polyaspartic acid of different molecular weight |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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