КФУ. Карточка публикации. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

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EMERGING ROLES OF THE SINGLE EF-HAND CA2+ SENSOR TESCALCIN IN THE REGULATION OF GENE EXPRESSION, CELL GROWTH AND DIFFERENTIATION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Колобынина Ксения Глебовна, автор

Ризванов Альберт Анатольевич, автор

Соловьева Валерия Владимировна, автор

Другие авторы

Levay Konstantin , автор

Slepak Vladlen , автор

Библиографическое описание на языке оригинала

Kolobynina K.G. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation / K.G. Kolobynina, V.V. Solovyova, K.Levay, A.A. Rizvanov, V.Z. Slepak // Journal of Cell Science. - 2016. - Р. 1-8.

Аннотация

Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal

Ключевые слова

CHP3, COP9, GSK3, NHE1, Differentiation, Tescalcin

Название журнала

Journal of Cell Science

Ссылка для РПД

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/104564/10.1242_jcs.191486.pdf?sequence=1&isAllowed=y

URL

http://jcs.biologists.org/content/early/2016/09/08/jcs.191486

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=139113

Файлы ресурса

Название файла	Размер (Мб)	Формат
10.1242_jcs.191486.pdf	0,46	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Колобынина Ксения Глебовна	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Соловьева Валерия Владимировна	ru_RU
dc.contributor.author	Levay Konstantin	ru_RU
dc.contributor.author	Slepak Vladlen	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Kolobynina K.G. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation / K.G. Kolobynina, V.V. Solovyova, K.Levay, A.A. Rizvanov, V.Z. Slepak // Journal of Cell Science. - 2016. - Р. 1-8.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=139113	ru_RU
dc.description.abstract	Journal of Cell Science	ru_RU
dc.description.abstract	Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	CHP3	ru_RU
dc.subject	COP9	ru_RU
dc.subject	GSK3	ru_RU
dc.subject	NHE1	ru_RU
dc.subject	Differentiation	ru_RU
dc.subject	Tescalcin	ru_RU
dc.title	Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU