КФУ. Карточка публикации. Tuning the non-covalent confinement of Gd(III) complexes in silicananoparticles for high T1-weighted MR imaging capability

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TUNING THE NON-COVALENT CONFINEMENT OF GD(III) COMPLEXES IN SILICANANOPARTICLES FOR HIGH T1-WEIGHTED MR IMAGING CAPABILITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Амиров Рустэм Рафаэльевич, автор

Заиров Рустэм Равилевич, автор

Степанов Алексей Степанович, автор

Фаттахова Альфия Нурлимановна, автор

Другие авторы

Fedorenko Svetlana , автор

Библиографическое описание на языке оригинала

Fedorenko S.V. Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T1-weighted MR imaging capability/ S.V. Fedorenko, Svetlana L. Grechkina, Asiya R. Mustafina, Kirill V. Kholin, Alexey S. Stepanov, Irek R. Nizameev, Ildus E. Ismaev, Marsil K. Kadirov, Rustem R. Zairova, Alfia N. Fattakhova, Rustem R. Amirov, Svetlana E. Soloveva // Colloids and Surfaces B: Biointerfaces. - 2017. -149. - 243–249.

Аннотация

The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres.The results highlight predominant contribution of the complexes located close to silica/water interface tothe relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloidsof the nanoparticles was exemplified by serum bovine albumin.

Ключевые слова

Positive contrast agents, Silica nanoparticles, MRI, Gd(III) complexes, Cytotoxicity

Название журнала

Colloids and Surfaces B: Biointerfaces

URL

http://dx.doi.org/10.1016/j.colsurfb.2016.10.025

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https://repository.kpfu.ru/?p_id=141340

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Амиров Рустэм Рафаэльевич	ru_RU
dc.contributor.author	Заиров Рустэм Равилевич	ru_RU
dc.contributor.author	Степанов Алексей Степанович	ru_RU
dc.contributor.author	Фаттахова Альфия Нурлимановна	ru_RU
dc.contributor.author	Fedorenko Svetlana	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Fedorenko S.V. Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T1-weighted MR imaging capability/ S.V. Fedorenko, Svetlana L. Grechkina, Asiya R. Mustafina, Kirill V. Kholin, Alexey S. Stepanov, Irek R. Nizameev, Ildus E. Ismaev, Marsil K. Kadirov, Rustem R. Zairova, Alfia N. Fattakhova, Rustem R. Amirov, Svetlana E. Soloveva // Colloids and Surfaces B: Biointerfaces. - 2017. -149. - 243–249.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=141340	ru_RU
dc.description.abstract	Colloids and Surfaces B: Biointerfaces	ru_RU
dc.description.abstract	The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres.The results highlight predominant contribution of the complexes located close to silica/water interface tothe relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloidsof the nanoparticles was exemplified by serum bovine albumin.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Positive contrast agents	ru_RU
dc.subject	Silica nanoparticles	ru_RU
dc.subject	MRI	ru_RU
dc.subject	Gd(III) complexes	ru_RU
dc.subject	Cytotoxicity	ru_RU
dc.title	Tuning the non-covalent confinement of Gd(III) complexes in silicananoparticles for high T1-weighted MR imaging capability	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU