Казанский (Приволжский) федеральный университет, КФУ
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THE STUDY OF THE DEPENDENCE OF PHLOGOTROPIC AND MEMBRANE-TROPIC ACTIVITY OF PHOSPHONATES ON THEIR CHEMICAL STRUCTURE
Форма представленияСтатьи в российских журналах и сборниках
Год публикации2016
Языканглийский
  • Зиганшина Лилия Евгеньевна, автор
  • Хазиахметова Вероника Николаевна, автор
  • Библиографическое описание на языке оригинала Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937.
    Аннотация This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi
    Ключевые слова phosphonates, dimephosphone, ephorane, carrageenin, inflammation, free radical hemolysis, red blood cell osmotic hemolysis, membrane-tropic activity, rats, mice.
    Название журнала Research Journal of Pharmaceutical, Biological and Chemical Sciences
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