| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Зиганшина Лилия Евгеньевна, автор
Хазиахметова Вероника Николаевна, автор
|
| Библиографическое описание на языке оригинала |
Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937. |
| Аннотация |
This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi |
| Ключевые слова |
phosphonates, dimephosphone, ephorane, carrageenin, inflammation, free radical hemolysis, red blood cell osmotic hemolysis, membrane-tropic activity, rats, mice. |
| Название журнала |
Research Journal of Pharmaceutical, Biological and Chemical Sciences
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=149212 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зиганшина Лилия Евгеньевна |
ru_RU |
| dc.contributor.author |
Хазиахметова Вероника Николаевна |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=149212 |
ru_RU |
| dc.description.abstract |
Research Journal of Pharmaceutical, Biological and Chemical Sciences |
ru_RU |
| dc.description.abstract |
This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
phosphonates |
ru_RU |
| dc.subject |
dimephosphone |
ru_RU |
| dc.subject |
ephorane |
ru_RU |
| dc.subject |
carrageenin |
ru_RU |
| dc.subject |
inflammation |
ru_RU |
| dc.subject |
free radical hemolysis |
ru_RU |
| dc.subject |
red blood cell osmotic hemolysis |
ru_RU |
| dc.subject |
membrane-tropic activity |
ru_RU |
| dc.subject |
rats |
ru_RU |
| dc.subject |
mice. |
ru_RU |
| dc.title |
The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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