КФУ. Карточка публикации. Anti-inflammatory activity of novel (S)-naproxen derivatives

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

ANTI-INFLAMMATORY ACTIVITY OF NOVEL (S)-NAPROXEN DERIVATIVES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Зиганшина Лилия Евгеньевна, автор

Конг Хонг Хань , автор

Курбангалиева Альмира Рафаэловна, автор

Латыпова Лилия Зиннуровна, автор

Авторы, аспиранты КФУ

Конг Хонг Хань, автор

Сибгатуллина Регина Рифатовна, автор

Библиографическое описание на языке оригинала

H. Cong, R. Sibgatullina, L. Latypova, A. Kurbangalieva, L. Ziganshina. Anti-inflammatory activity of novel (S)-naproxen derivatives // BioNanoSci. - 2017. - V. 7. - № 1. - P. 189-193.

Аннотация

In order to optimize the study of the antiinflammatory activity of novel drugs, in the current study, we used simple in vitro test system, which included osmotic and free radical hemolysis of human erythrocytes and human platelets aggregation, to screen for potential anti-inflammatory activity of three newly developed (S)-naproxen derivatives. We selected one of them (L3), which performed in in vitro tests nearly as well as naproxen, and studied their anti-inflammatory effects on in vivo model of inflammation, induced by carragenan. L3 was comparable to naproxen in its anti-inflammatory effects, suggesting that the studied simple inexpensive in vitro tests of erythrocyte osmotic and free radical hemolysis and human platelets aggregation could be used for pre-screening of potential anti-inflammatory agents.

Ключевые слова

Hemolysis, platelet aggregation, carrageenan, anti-inflammatory drugs, naproxen, 2(5H)-furanone

Название журнала

BioNanoScience

URL

https://link.springer.com/article/10.1007/s12668-016-0329-3

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=153362

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зиганшина Лилия Евгеньевна	ru_RU
dc.contributor.author	Конг Хонг Хань	ru_RU
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.contributor.author	Латыпова Лилия Зиннуровна	ru_RU
dc.contributor.author	Конг Хонг Хань	ru_RU
dc.contributor.author	Сибгатуллина Регина Рифатовна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	H. Cong, R. Sibgatullina, L. Latypova, A. Kurbangalieva, L. Ziganshina. Anti-inflammatory activity of novel (S)-naproxen derivatives // BioNanoSci. - 2017. - V. 7. - № 1. - P. 189-193.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=153362	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	In order to optimize the study of the antiinflammatory activity of novel drugs, in the current study, we used simple in vitro test system, which included osmotic and free radical hemolysis of human erythrocytes and human platelets aggregation, to screen for potential anti-inflammatory activity of three newly developed (S)-naproxen derivatives. We selected one of them (L3), which performed in in vitro tests nearly as well as naproxen, and studied their anti-inflammatory effects on in vivo model of inflammation, induced by carragenan. L3 was comparable to naproxen in its anti-inflammatory effects, suggesting that the studied simple inexpensive in vitro tests of erythrocyte osmotic and free radical hemolysis and human platelets aggregation could be used for pre-screening of potential anti-inflammatory agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hemolysis	ru_RU
dc.subject	platelet aggregation	ru_RU
dc.subject	carrageenan	ru_RU
dc.subject	anti-inflammatory drugs	ru_RU
dc.subject	naproxen	ru_RU
dc.subject	2(5H)-furanone	ru_RU
dc.title	Anti-inflammatory activity of novel (S)-naproxen derivatives	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU