КФУ. Карточка публикации. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats

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NPY1 RECEPTORS PARTICIPATE IN THE REGULATION OF MYOCARDIAL CONTRACTILITY IN RATS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Аникина Татьяна Андреевна, автор

Зверев Алексей Анатольевич, автор

Зефиров Тимур Львович, автор

Крылова Алевтина Васильевна, автор

Другие авторы

Masliukov Petor Mikhailovich, автор

Библиографическое описание на языке оригинала

Masliukov, P.M. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats / P.M. Masliukov, T.A. Anikina, A.A Zverev, A.V. Krylova, K.Y. Moiseev, T.L. Zefirov // Bulletin of Experimental Biology and Medicine, - 2017, № 2, - P.418-420

Аннотация

Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10—7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1 receptors in myocardial contraction

Ключевые слова

neuropeptide Ytypes of NPY receptorsmyocardial contractilityrat

Название журнала

Bulletin of Experimental Biology and Medicine

URL

http://link.springer.com/article/10.1007%2Fs10517-017-3629-x

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https://repository.kpfu.ru/?p_id=153471

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Аникина Татьяна Андреевна	ru_RU
dc.contributor.author	Зверев Алексей Анатольевич	ru_RU
dc.contributor.author	Зефиров Тимур Львович	ru_RU
dc.contributor.author	Крылова Алевтина Васильевна	ru_RU
dc.contributor.author	Masliukov Petor Mikhailovich	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Masliukov, P.M. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats / P.M. Masliukov, T.A. Anikina, A.A Zverev, A.V. Krylova, K.Y. Moiseev, T.L. Zefirov // Bulletin of Experimental Biology and Medicine, - 2017, № 2, - P.418-420	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=153471	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10—7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1 receptors in myocardial contraction	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU