| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2017 |
| Язык | русский |
|
Ситдикова Гузель Фаритовна, автор
|
| Библиографическое описание на языке оригинала |
Julia Lebedeva1,2,3,?, Andrei Zakharov1,4,?, Elena Ogievetsky2,3, Alina Minlebaeva2,3, Rustem Kurbanov1, Elena Gerasimova1, Guzel Sitdikova1,? and Roustem Khazipov1 Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo // Cerebral Cortex, February 2017;27: 1068–1082 |
| Аннотация |
Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and
neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity.
However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity.We explored the effects of alcohol
(1–6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1–23 and compared them with its
apoptotic actions. At P4–7, when the peak of alcohol-induced apoptosiswas observed, alcohol strongly suppressed spontaneous
gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of
suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly
inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns.
The suppressive effe |
| Ключевые слова |
apoptosis, electroencephalogram, ethanol, fetal alcohol syndrome, neonate, neuronal network, rat, sensory-evoked
potentials |
| Название журнала |
Cerebral Cortex
|
| URL |
https://academic.oup.com/cercor/article/27/2/1068/3056288/Inhibition-of-Cortical-Activity-and-Apoptosis |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=154353 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Ситдикова Гузель Фаритовна |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Julia Lebedeva1,2,3,?, Andrei Zakharov1,4,?, Elena Ogievetsky2,3, Alina Minlebaeva2,3, Rustem Kurbanov1, Elena Gerasimova1, Guzel Sitdikova1,? and Roustem Khazipov1 Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo // Cerebral Cortex, February 2017;27: 1068–1082 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=154353 |
ru_RU |
| dc.description.abstract |
Cerebral Cortex |
ru_RU |
| dc.description.abstract |
Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and
neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity.
However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity.We explored the effects of alcohol
(1–6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1–23 and compared them with its
apoptotic actions. At P4–7, when the peak of alcohol-induced apoptosiswas observed, alcohol strongly suppressed spontaneous
gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of
suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly
inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns.
The suppressive effe |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
apoptosis |
ru_RU |
| dc.subject |
electroencephalogram |
ru_RU |
| dc.subject |
ethanol |
ru_RU |
| dc.subject |
fetal alcohol syndrome |
ru_RU |
| dc.subject |
neonate |
ru_RU |
| dc.subject |
neuronal network |
ru_RU |
| dc.subject |
rat |
ru_RU |
| dc.subject |
sensory-evoked
potentials |
ru_RU |
| dc.title |
Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
