КФУ. Карточка публикации. Effects of Haloperidol on Acute Carrageenan-Induced Inflammation

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EFFECTS OF HALOPERIDOL ON ACUTE CARRAGEENAN-INDUCED INFLAMMATION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Зиганшина Лилия Евгеньевна, автор

Конг Хонг Хань , автор

Хазиахметова Вероника Николаевна, автор

Библиографическое описание на языке оригинала

Khaziakhmetova V.The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation/Khaziakhmetova, V., Baiysbekov K., Torobekov Sh., Hanh Cong, Ziganshina L. // NanoBioScience. - 2017 – pp 442–445 DOI: 10.1007/s12668-017-0392-4.

Аннотация

The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer's, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.

Ключевые слова

Acute inflammation, Carrageenan, Haloperidol,Rats

Название журнала

Springerlink

URL

http://link.springer.com/article/10.1007/s12668-017-0392-4

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https://repository.kpfu.ru/?p_id=154411

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зиганшина Лилия Евгеньевна	ru_RU
dc.contributor.author	Конг Хонг Хань	ru_RU
dc.contributor.author	Хазиахметова Вероника Николаевна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Khaziakhmetova V.The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation/Khaziakhmetova, V., Baiysbekov K., Torobekov Sh., Hanh Cong, Ziganshina L. // NanoBioScience. - 2017 – pp 442–445 DOI: 10.1007/s12668-017-0392-4.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=154411	ru_RU
dc.description.abstract	Springerlink	ru_RU
dc.description.abstract	The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer's, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acute inflammation	ru_RU
dc.subject	Carrageenan	ru_RU
dc.subject	Haloperidol	ru_RU
dc.subject	Rats	ru_RU
dc.title	Effects of Haloperidol on Acute Carrageenan-Induced Inflammation	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU