КФУ. Карточка публикации. Preferential Solvation/Hydration of α-Chymotrypsin in Water

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PREFERENTIAL SOLVATION/HYDRATION OF α-CHYMOTRYPSIN IN WATER&NDASH;ACETONITRILE MIXTURES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Сироткин Владимир Александрович, автор

Авторы, студенты КФУ

Кучиерская Александра Александровна, автор

Библиографическое описание на языке оригинала

Sirotkin, V.A. Preferential Solvation/Hydration of α-Chymotrypsin in Water–Acetonitrile Mixtures [Text]/ V. A. Sirotkin, A.A. Kuchierskaya // Journal of Physical Chemistry B. - 2017. - Vol. 121. - P. 4422-4430. ISSN: 1520-6106.

Аннотация

The aim of our study is to monitor the preferential hydration/solvation of the protein macromolecules at low and high water content in water–organic mixtures. Our approach is based on the analysis of the absolute values of the water/organic solvent sorption. We applied this approach to estimate the protein stabilization/destabilization due to the preferential interactions of α-chymotrypsin with water–acetonitrile mixtures. Advantages of our approach: (i) The preferential interaction parameters can be determined in the entire range of water content in water–organic mixtures. (ii) Our approach facilitates the individual evaluation of the Gibbs energies of water, protein, and organic solvent.

Ключевые слова

Preferential solvation, Protein hydration, Water, Organic solvent, Acetonitrile

Название журнала

J PHYS CHEM B

URL

http://pubs.acs.org/doi/abs/10.1021/acs.jpcb.7b01632

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https://repository.kpfu.ru/?p_id=157387

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Сироткин Владимир Александрович	ru_RU
dc.contributor.author	Кучиерская Александра Александровна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Sirotkin, V.A. Preferential Solvation/Hydration of α-Chymotrypsin in Water–Acetonitrile Mixtures [Text]/ V. A. Sirotkin, A.A. Kuchierskaya // Journal of Physical Chemistry B. - 2017. - Vol. 121. - P. 4422-4430. ISSN: 1520-6106.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=157387	ru_RU
dc.description.abstract	J PHYS CHEM B	ru_RU
dc.description.abstract	The aim of our study is to monitor the preferential hydration/solvation of the protein macromolecules at low and high water content in water–organic mixtures. Our approach is based on the analysis of the absolute values of the water/organic solvent sorption. We applied this approach to estimate the protein stabilization/destabilization due to the preferential interactions of α-chymotrypsin with water–acetonitrile mixtures. Advantages of our approach: (i) The preferential interaction parameters can be determined in the entire range of water content in water–organic mixtures. (ii) Our approach facilitates the individual evaluation of the Gibbs energies of water, protein, and organic solvent.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Preferential solvation	ru_RU
dc.subject	Protein hydration	ru_RU
dc.subject	Water	ru_RU
dc.subject	Organic solvent	ru_RU
dc.subject	Acetonitrile	ru_RU
dc.title	Preferential Solvation/Hydration of α-Chymotrypsin in Water–Acetonitrile Mixtures	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU