| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2017 |
| Язык | английский |
|
Герасимова Елена Вячеславовна, автор
Закирова Гульшат Фоатовна, автор
Зиятдинова Гузель Камилевна, автор
Ситдикова Гузель Фаритовна, автор
Хаертдинов Наиль Назимович, автор
Яковлева Ольга Владиславовна, автор
|
| Библиографическое описание на языке оригинала |
Gerasimova Е. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring / E. Gerasimova, O. Yakovleva, G. Burkhanova, G. Ziyatdinova, N. Khaertdinov, G. Sitdikova // BioNanoScience. - 2017. - V. 7. - № 1. - P. 155-158. |
| Аннотация |
During pregnancy, several complications have been associated with hyperhomocysteinemia and elevated homocysteine (Hcy) levels have been shown to play a role in the etiology of preeclampsia, placental abruption, intrauterine growth retardation, and neural tube defects. In the present work we aimed to investigate the effects of maternal Hcy on the development and neurobehavioral maturation of the offspring. On the pups, we performed a follow-up of classical parameters of development such as body weight, eyelid opening, ear unfolding, incisor eruption and the appearance of hair, and subjected the pups to various tests representative of neurobehavioral maturation extending from 4th to 20th postnatal days (righting reflex, negative geotaxis, cliff avoidance, head shake, acoustic startle reflex, free-fall righting, cliff avoidance caused by visual stimulus, olfactory discrimination). We have shown that newborn animals were characterized by lower body weight and higher mortality. |
| Ключевые слова |
Maternal hyperhomocysteinemia, neonatal development, rat, neurobehavioral maturation |
| Название журнала |
BioNanoScience
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017594216&doi=10.1007%2fs12668-016-0326-6&partnerID=40&md5=246e07ce263481025c51a9bfb54cc63d |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=157851 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Герасимова Елена Вячеславовна |
ru_RU |
| dc.contributor.author |
Закирова Гульшат Фоатовна |
ru_RU |
| dc.contributor.author |
Зиятдинова Гузель Камилевна |
ru_RU |
| dc.contributor.author |
Ситдикова Гузель Фаритовна |
ru_RU |
| dc.contributor.author |
Хаертдинов Наиль Назимович |
ru_RU |
| dc.contributor.author |
Яковлева Ольга Владиславовна |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Gerasimova Е. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring / E. Gerasimova, O. Yakovleva, G. Burkhanova, G. Ziyatdinova, N. Khaertdinov, G. Sitdikova // BioNanoScience. - 2017. - V. 7. - № 1. - P. 155-158. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=157851 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
During pregnancy, several complications have been associated with hyperhomocysteinemia and elevated homocysteine (Hcy) levels have been shown to play a role in the etiology of preeclampsia, placental abruption, intrauterine growth retardation, and neural tube defects. In the present work we aimed to investigate the effects of maternal Hcy on the development and neurobehavioral maturation of the offspring. On the pups, we performed a follow-up of classical parameters of development such as body weight, eyelid opening, ear unfolding, incisor eruption and the appearance of hair, and subjected the pups to various tests representative of neurobehavioral maturation extending from 4th to 20th postnatal days (righting reflex, negative geotaxis, cliff avoidance, head shake, acoustic startle reflex, free-fall righting, cliff avoidance caused by visual stimulus, olfactory discrimination). We have shown that newborn animals were characterized by lower body weight and higher mortality. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Maternal hyperhomocysteinemia |
ru_RU |
| dc.subject |
neonatal development |
ru_RU |
| dc.subject |
rat |
ru_RU |
| dc.subject |
neurobehavioral maturation |
ru_RU |
| dc.title |
Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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