| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2017 |
| Язык | английский |
|
Балакин Константин Валерьевич, автор
Булатова Елена Сергеевна, автор
Гришаев Денис Юрьевич, автор
Иксанова Альфия Габдулахатовна, автор
Каюмов Айрат Рашитович, автор
Никитина Елена Владимировна, автор
Сапожников Сергей Витальевич, автор
Штырлин Никита Валерьевич, автор
Штырлин Юрий Григорьевич, автор
|
|
Замальдинова Алина Эльбрусовна, автор
|
| Библиографическое описание на языке оригинала |
Sapozhnikov S.V. New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity / S.V. Sapozhnikov, N.V. Shtyrlin, A.R. Kayumov, A.E. Zamaldinova, A.G. Iksanova, Е.V. Nikitina, Е.S. Krylova, D.Yu. Grishaev, K.V. Balakin, Y.G. Shtyrlin // Medicinal Chemistry Research. - 2017. - V.26(12). - P. 3188-3202. |
| Аннотация |
A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine derivatives was synthesized, and their antibacterial activity against several clinically relevant bacterial strains was evaluated in vitro. Several mono-ammonium compounds demonstrated high antibacterial activity against methicillin-resistant Staphylococcus strains with minimum inhibitory concentrations in the range of 0.5–8 ?g/mL, which exceeded activity of miramistin and was comparable to that of benzalkonium chloride. SOS-chromotest in Salmonella typhimurium showed the lack of DNA-damage activity for all active compounds. A clear correlation has been observed between the lipophilicity of the obtained compounds and their activity against the studied Gram-positive bacterial strains. Cytotoxicity studies on HEK-293 cells demonstrated that some of the active compounds were less toxic than the reference drugs. Antibacterial activity studies in the presence of CaCl2 suggested that the cell wall damage associa |
| Ключевые слова |
Quaternary ammonium salts, Pyridoxine, Antibacterial activit,y Cytotoxicity, Genotoxicity, Cell wall damaging agents |
| Название журнала |
Medicinal Chemistry Research
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028330282&doi=10.1007%2fs00044-017-2012-9&partnerID=40&md5=b0052601b01b79687ee14f788471aa44 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=164444 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Балакин Константин Валерьевич |
ru_RU |
| dc.contributor.author |
Булатова Елена Сергеевна |
ru_RU |
| dc.contributor.author |
Гришаев Денис Юрьевич |
ru_RU |
| dc.contributor.author |
Иксанова Альфия Габдулахатовна |
ru_RU |
| dc.contributor.author |
Каюмов Айрат Рашитович |
ru_RU |
| dc.contributor.author |
Никитина Елена Владимировна |
ru_RU |
| dc.contributor.author |
Сапожников Сергей Витальевич |
ru_RU |
| dc.contributor.author |
Штырлин Никита Валерьевич |
ru_RU |
| dc.contributor.author |
Штырлин Юрий Григорьевич |
ru_RU |
| dc.contributor.author |
Замальдинова Алина Эльбрусовна |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Sapozhnikov S.V. New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity / S.V. Sapozhnikov, N.V. Shtyrlin, A.R. Kayumov, A.E. Zamaldinova, A.G. Iksanova, Е.V. Nikitina, Е.S. Krylova, D.Yu. Grishaev, K.V. Balakin, Y.G. Shtyrlin // Medicinal Chemistry Research. - 2017. - V.26(12). - P. 3188-3202. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=164444 |
ru_RU |
| dc.description.abstract |
Medicinal Chemistry Research |
ru_RU |
| dc.description.abstract |
A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine derivatives was synthesized, and their antibacterial activity against several clinically relevant bacterial strains was evaluated in vitro. Several mono-ammonium compounds demonstrated high antibacterial activity against methicillin-resistant Staphylococcus strains with minimum inhibitory concentrations in the range of 0.5–8 ?g/mL, which exceeded activity of miramistin and was comparable to that of benzalkonium chloride. SOS-chromotest in Salmonella typhimurium showed the lack of DNA-damage activity for all active compounds. A clear correlation has been observed between the lipophilicity of the obtained compounds and their activity against the studied Gram-positive bacterial strains. Cytotoxicity studies on HEK-293 cells demonstrated that some of the active compounds were less toxic than the reference drugs. Antibacterial activity studies in the presence of CaCl2 suggested that the cell wall damage associa |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Quaternary ammonium salts |
ru_RU |
| dc.subject |
Pyridoxine |
ru_RU |
| dc.subject |
Antibacterial activit |
ru_RU |
| dc.subject |
y Cytotoxicity |
ru_RU |
| dc.subject |
Genotoxicity |
ru_RU |
| dc.subject |
Cell wall damaging agents |
ru_RU |
| dc.title |
New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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