| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2017 |
| Язык | английский |
|
Вафина Рузалия Масхутовна, автор
Евтюгин Владимир Геннадьевич, автор
Зелди Марина Ивановна, автор
Каюмов Айрат Рашитович, автор
Никитина Елена Владимировна, автор
Пугачев Михаил Владимирович, автор
Федосимова Светлана Владимировна, автор
Штырлин Никита Валерьевич, автор
Штырлин Юрий Григорьевич, автор
|
| Библиографическое описание на языке оригинала |
Nikitina E.V. Elucidation of the Mode of Action of New Antibacterial Bis-Phosphonium Salts of Pyridine Derivatives Active Against Staphylococcus aureus / E.V. Nikitina, M.I. Zeldi, R.M. Vafina, M.V. Pugachev, N.V. Shtyrlin, S.V. Kuznetsova, V.G. Evtugyn, A.R. Kayumov, Y.G. Shtyrlin // RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES. - 2017. - V.8, Is.3. - P.1906-1915. |
| Аннотация |
In this study, we show the antibacterial activity of a new group of antimicrobial compounds,
quaternary bis-phosphonium salts of pyridine derivatives synthesized previously in our group. These
compounds exhibit broad-spectrum of antibacterial activity against gram-positive bacteria including
methicillin-resistant strains of Staphylococcus aureus. By using both scanning and transmission electron
microscopy we found that the lead compound 6-Bis[(tri-p-tolylphosphonio)methyl]-3-hydroxypyridin-1-ium
trichloride (2a) bearing two p-tolyl substituents at the phosphorus atoms exhibits a highest antibacterial
activity and affects the cell wall of S. aureus, which results in filamentous growth, roughened surface of cells
with excrescences and unusual protrusions. While the confocal scanning microscopy showed only partial loss
of membrane integrity at 1×MIC of 2a, TEM studies revealed that 2a exerts cell wall damage resulting in breaks
and diffuse structure of peptidoglycan layer, which is likely |
| Ключевые слова |
quaternary phosphonium salts, pyridine, antibacterial activity, microscopy |
| Название журнала |
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES
|
| URL |
https://www.rjpbcs.com/pdf/2017_8(3)/[223].pdf |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=168670 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Вафина Рузалия Масхутовна |
ru_RU |
| dc.contributor.author |
Евтюгин Владимир Геннадьевич |
ru_RU |
| dc.contributor.author |
Зелди Марина Ивановна |
ru_RU |
| dc.contributor.author |
Каюмов Айрат Рашитович |
ru_RU |
| dc.contributor.author |
Никитина Елена Владимировна |
ru_RU |
| dc.contributor.author |
Пугачев Михаил Владимирович |
ru_RU |
| dc.contributor.author |
Федосимова Светлана Владимировна |
ru_RU |
| dc.contributor.author |
Штырлин Никита Валерьевич |
ru_RU |
| dc.contributor.author |
Штырлин Юрий Григорьевич |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Nikitina E.V. Elucidation of the Mode of Action of New Antibacterial Bis-Phosphonium Salts of Pyridine Derivatives Active Against Staphylococcus aureus / E.V. Nikitina, M.I. Zeldi, R.M. Vafina, M.V. Pugachev, N.V. Shtyrlin, S.V. Kuznetsova, V.G. Evtugyn, A.R. Kayumov, Y.G. Shtyrlin // RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES. - 2017. - V.8, Is.3. - P.1906-1915. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=168670 |
ru_RU |
| dc.description.abstract |
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES |
ru_RU |
| dc.description.abstract |
In this study, we show the antibacterial activity of a new group of antimicrobial compounds,
quaternary bis-phosphonium salts of pyridine derivatives synthesized previously in our group. These
compounds exhibit broad-spectrum of antibacterial activity against gram-positive bacteria including
methicillin-resistant strains of Staphylococcus aureus. By using both scanning and transmission electron
microscopy we found that the lead compound 6-Bis[(tri-p-tolylphosphonio)methyl]-3-hydroxypyridin-1-ium
trichloride (2a) bearing two p-tolyl substituents at the phosphorus atoms exhibits a highest antibacterial
activity and affects the cell wall of S. aureus, which results in filamentous growth, roughened surface of cells
with excrescences and unusual protrusions. While the confocal scanning microscopy showed only partial loss
of membrane integrity at 1×MIC of 2a, TEM studies revealed that 2a exerts cell wall damage resulting in breaks
and diffuse structure of peptidoglycan layer, which is likely |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
quaternary phosphonium salts |
ru_RU |
| dc.subject |
pyridine |
ru_RU |
| dc.subject |
antibacterial activity |
ru_RU |
| dc.subject |
microscopy |
ru_RU |
| dc.title |
Elucidation of the Mode of Action of New Antibacterial Bis-Phosphonium Salts of Pyridine Derivatives Active Against Staphylococcus aureus |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
