КФУ. Карточка публикации. Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus

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POSTSYNAPTIC GABA(B) RECEPTORS CONTRIBUTE TO THE TERMINATION OF GIANT DEPOLARIZING POTENTIALS IN CA3 NEONATAL RAT HIPPOCAMPUS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Минлебаев Марат Гусманович, автор

Мухтаров Марат Рахимзянович, автор

Хазипов Рустем Нариманович, автор

Халилов Илгам Адегамович, автор

Авторы, аспиранты КФУ

Юзекаева Эльвира Разилевна, автор

Библиографическое описание на языке оригинала

Khalilov I.Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus / I. Khalilov, M. Minlebaev, M. Mukhtarov, E. Juzekaeva, R. Khazipov // Front Cell Neurosci. ? 2017.

Аннотация

During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and ﬁring of CA3 pyramidal cells followed by afterhyperpolarization (GDP-AHP). Here, we explored the properties of GDP-AHP in CA3 pyramidal cells using gramicidin perforated patch clamp recordings from neonatal rat hippocampal slices. We found that GDP-AHP occurs independently of whether CA3 pyramidal cells ﬁre action potentials (APs) or remain silent during GDPs. However, the amplitude of GDP-AHP increased with the number of APs the cells ﬁred during GDPs. The reversal potential of the GDP-AHP was close to the potassium equilibrium potential.

Ключевые слова

GABA, giant depolarizing potentials, neonatal, hippocampus, patch-clamp techniques, development

Название журнала

Frontiers in Cellular Neuroscience

URL

https://www.frontiersin.org/articles/10.3389/fncel.2017.00179/full

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https://repository.kpfu.ru/?p_id=173304

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Минлебаев Марат Гусманович	ru_RU
dc.contributor.author	Мухтаров Марат Рахимзянович	ru_RU
dc.contributor.author	Хазипов Рустем Нариманович	ru_RU
dc.contributor.author	Халилов Илгам Адегамович	ru_RU
dc.contributor.author	Юзекаева Эльвира Разилевна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Khalilov I.Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus / I. Khalilov, M. Minlebaev, M. Mukhtarov, E. Juzekaeva, R. Khazipov // Front Cell Neurosci. ? 2017.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=173304	ru_RU
dc.description.abstract	Frontiers in Cellular Neuroscience	ru_RU
dc.description.abstract	During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and ﬁring of CA3 pyramidal cells followed by afterhyperpolarization (GDP-AHP). Here, we explored the properties of GDP-AHP in CA3 pyramidal cells using gramicidin perforated patch clamp recordings from neonatal rat hippocampal slices. We found that GDP-AHP occurs independently of whether CA3 pyramidal cells ﬁre action potentials (APs) or remain silent during GDPs. However, the amplitude of GDP-AHP increased with the number of APs the cells ﬁred during GDPs. The reversal potential of the GDP-AHP was close to the potassium equilibrium potential.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	GABA	ru_RU
dc.subject	giant depolarizing potentials	ru_RU
dc.subject	neonatal	ru_RU
dc.subject	hippocampus	ru_RU
dc.subject	patch-clamp techniques	ru_RU
dc.subject	development	ru_RU
dc.title	Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU