КФУ. Карточка публикации. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms

RUS

- EN
- 中文
- ES

FLUCONAZOLE-PYRIDOXINE BIS-TRIAZOLIUM COMPOUNDS WITH POTENT ACTIVITY AGAINST PATHOGENIC BACTERIA AND FUNGI INCLUDING THEIR BIOFILM-EMBEDDED FORMS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Аймалетдинов Александр Маазович, автор

Балакин Константин Валерьевич, автор

Бондарь Оксана Викторовна, автор

Гарипов Марсель Радыикович, автор

Иксанова Альфия Габдулахатовна, автор

Каюмов Айрат Рашитович, автор

Лисовская Светлана Анатольевна, автор

Маланьева Альбина Геннадьевна, автор

Никитина Елена Владимировна, автор

Павельев Роман Сергеевич, автор

Сабирова Алина Эльбрусовна, автор

Штырлин Юрий Григорьевич, автор

Библиографическое описание на языке оригинала

Garipov M.R. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms / M.R. Garipov, R.S. Pavelyev, S.A. Lisovskaya, E.V. Nikitina, A.R. Kayumov, A.E. Sabirova, O.V. Bondar, A.G. Malanyeva, A.M. Aimaletdinov, A.G. Iksanova, K.V. Balakin, Y.G. Shtyrlin // Journal of Chemistry. - 2017. - Art. №4761650.

Аннотация

Two novel quaternary ammonium salts, bis-triazolium derivatives of fluconazole and pyridoxine, were synthesized by reaction of fluconazole with pyridoxine-based synthetic intermediates. The leading compound demonstrated pronounced antimycotic and antibacterial in vitro activity, comparable to or exceeding that of the reference antifungal (fluconazole, terbinafine) and antibacterial/antiseptic (miramistin, benzalkonium chloride) agents. In contrast to many antimicrobials, the leading compound was also active against biofilm-embedded staphylococci and Escherichia coli. While no biofilm structure destruction occurred, all compounds were able to diffuse into the matrix and reduce the number of colony-forming units by three orders of magnitude at 16 × MBC. The leading compound was significantly less toxic than miramistin and benzalkonium chloride and more toxic than the reference antifungal drugs. The obtained results make the described chemotype a promising starting point for the developme

Ключевые слова

Pathogenic Bacteria

Название журнала

Journal of Chemistry

URL

https://www.hindawi.com/journals/jchem/2017/4761650/

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=174101

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Аймалетдинов Александр Маазович	ru_RU
dc.contributor.author	Балакин Константин Валерьевич	ru_RU
dc.contributor.author	Бондарь Оксана Викторовна	ru_RU
dc.contributor.author	Гарипов Марсель Радыикович	ru_RU
dc.contributor.author	Иксанова Альфия Габдулахатовна	ru_RU
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.contributor.author	Лисовская Светлана Анатольевна	ru_RU
dc.contributor.author	Маланьева Альбина Геннадьевна	ru_RU
dc.contributor.author	Никитина Елена Владимировна	ru_RU
dc.contributor.author	Павельев Роман Сергеевич	ru_RU
dc.contributor.author	Сабирова Алина Эльбрусовна	ru_RU
dc.contributor.author	Штырлин Юрий Григорьевич	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Garipov M.R. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms / M.R. Garipov, R.S. Pavelyev, S.A. Lisovskaya, E.V. Nikitina, A.R. Kayumov, A.E. Sabirova, O.V. Bondar, A.G. Malanyeva, A.M. Aimaletdinov, A.G. Iksanova, K.V. Balakin, Y.G. Shtyrlin // Journal of Chemistry. - 2017. - Art. №4761650.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=174101	ru_RU
dc.description.abstract	Journal of Chemistry	ru_RU
dc.description.abstract	Two novel quaternary ammonium salts, bis-triazolium derivatives of fluconazole and pyridoxine, were synthesized by reaction of fluconazole with pyridoxine-based synthetic intermediates. The leading compound demonstrated pronounced antimycotic and antibacterial in vitro activity, comparable to or exceeding that of the reference antifungal (fluconazole, terbinafine) and antibacterial/antiseptic (miramistin, benzalkonium chloride) agents. In contrast to many antimicrobials, the leading compound was also active against biofilm-embedded staphylococci and Escherichia coli. While no biofilm structure destruction occurred, all compounds were able to diffuse into the matrix and reduce the number of colony-forming units by three orders of magnitude at 16 × MBC. The leading compound was significantly less toxic than miramistin and benzalkonium chloride and more toxic than the reference antifungal drugs. The obtained results make the described chemotype a promising starting point for the developme	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU