| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2018 |
| Язык | английский |
|
Захаров Андрей Викторович, автор
Курмашова Евгения Денисовна, автор
Яковлев Алексей Валерьевич, автор
|
| Библиографическое описание на языке оригинала |
Yakovlev A.V. Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia/ Yakovlev AV, Kurmashova E, Zakharov A., Sitdikova GF // BioNanoScience
March 2018, Volume 8, Issue 1, pp 304–309 |
| Аннотация |
Maternal hyperhomocysteinemia (HHCy) correlated with a number of complications such as abruption placentae, preeclampsia syndrome, in utero fetal death and fetal neural tube defects, cognitive impairment, and neurodegeneration during postnatal development. In the present study, we investigated the effects of prenatal HHCy on electrophysiological features and spontaneous network activity of neurons in hippocampus of rats of the first postnatal week. The analysis of intrinsic electrophysiological properties of pyramidal neurons has shown the decrease of the membrane capacitance and the threshold of generation of action potentials in rats with prenatal HHCy without alteration of the input resistance and resting membrane potential. In trains of action potentials elicited with prolonged current injections, an increase of interspike intervals and a broadening of action potentials during repetitive firing were observed in control neurons. In the neurons of pups with prenatal HHCy, the changes |
| Ключевые слова |
Maternal hyperhomocysteinemia Hippocampus Giant depolarizing potentials Neuronal excitability |
| Название журнала |
BioNanoScience
|
| URL |
https://link.springer.com/article/10.1007/s12668-017-0450-y |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=178323 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Захаров Андрей Викторович |
ru_RU |
| dc.contributor.author |
Курмашова Евгения Денисовна |
ru_RU |
| dc.contributor.author |
Яковлев Алексей Валерьевич |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
Yakovlev A.V. Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia/ Yakovlev AV, Kurmashova E, Zakharov A., Sitdikova GF // BioNanoScience
March 2018, Volume 8, Issue 1, pp 304–309 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=178323 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
Maternal hyperhomocysteinemia (HHCy) correlated with a number of complications such as abruption placentae, preeclampsia syndrome, in utero fetal death and fetal neural tube defects, cognitive impairment, and neurodegeneration during postnatal development. In the present study, we investigated the effects of prenatal HHCy on electrophysiological features and spontaneous network activity of neurons in hippocampus of rats of the first postnatal week. The analysis of intrinsic electrophysiological properties of pyramidal neurons has shown the decrease of the membrane capacitance and the threshold of generation of action potentials in rats with prenatal HHCy without alteration of the input resistance and resting membrane potential. In trains of action potentials elicited with prolonged current injections, an increase of interspike intervals and a broadening of action potentials during repetitive firing were observed in control neurons. In the neurons of pups with prenatal HHCy, the changes |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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