| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2018 |
| Язык | английский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Хабибрахманов Инсаф Илхамович, автор
|
|
Zefirova J. , автор
|
| Библиографическое описание на языке оригинала |
Zefirov T.L. The influence of methoxamine on the isolated heart chronotropy and inotropy / T.L. Zefirov, I.I. Khabibrakhmanov, J.T. Zefirova, N.I. Ziyatdinova // European Journal of Clinical Investigation. -2018. - Vol. 48, S.1. -P. 139. |
| Аннотация |
The stimulation of α1-ARs with MX induced bradycardia in isolated heart. Still in our experiments all studied concentrations of methoxamine induced negative inotropic reaction of isolated left ventricle of rats. The intensity of the negative inotropic effect depended on concentration of the agonist.
Decreased heart rate and myocardium contractility with activation of α1-AR may be secondary to decreased ICa due activation of protein kinase C. It?s quite possible that α1-AR participate in more delicate regulation of cardiac function and most likely effects of stimulation depend on activity of other receptors and different intracellular systems.
|
| Ключевые слова |
Rat, heart, alpha1-adrenoceptors, metoxamine. |
| Название журнала |
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
|
| URL |
https://onlinelibrary.wiley.com/toc/13652362/2018/48/S1 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=181926 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Хабибрахманов Инсаф Илхамович |
ru_RU |
| dc.contributor.author |
Zefirova J. |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
Zefirov T.L. The influence of methoxamine on the isolated heart chronotropy and inotropy / T.L. Zefirov, I.I. Khabibrakhmanov, J.T. Zefirova, N.I. Ziyatdinova // European Journal of Clinical Investigation. -2018. - Vol. 48, S.1. -P. 139. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=181926 |
ru_RU |
| dc.description.abstract |
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION |
ru_RU |
| dc.description.abstract |
The stimulation of α1-ARs with MX induced bradycardia in isolated heart. Still in our experiments all studied concentrations of methoxamine induced negative inotropic reaction of isolated left ventricle of rats. The intensity of the negative inotropic effect depended on concentration of the agonist.
Decreased heart rate and myocardium contractility with activation of α1-AR may be secondary to decreased ICa due activation of protein kinase C. It?s quite possible that α1-AR participate in more delicate regulation of cardiac function and most likely effects of stimulation depend on activity of other receptors and different intracellular systems.
|
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Rat |
ru_RU |
| dc.subject |
heart |
ru_RU |
| dc.subject |
alpha1-adrenoceptors |
ru_RU |
| dc.subject |
metoxamine. |
ru_RU |
| dc.title |
The influence of methoxamine on the isolated heart chronotropy and inotropy |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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