КФУ. Карточка публикации. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

NMR STUDY OF CONFORMATIONAL STRUCTURE OF FLUVASTATIN AND ITS COMPLEX WITH DODECYLPHOSPHOCHOLINE MICELLES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Авторы, сотрудники КФУ

Аганов Альберт Вартанович, автор

Галиуллина Лейсан Фаритовна, автор

Клочков Владимир Васильевич, автор

Латфуллин Ильдус Анварович, автор

Авторы, аспиранты КФУ

Мусабирова Гузель Салаватовна, автор

Библиографическое описание на языке оригинала

L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles // BioNanoScience, V. 6, 2016.-P. 352-354.

Аннотация

Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.

Ключевые слова

Nuclear magnetic resonance, Fluvastatin, Micelles, Molecular complex

Название журнала

BioNanoScience

URL

https://doi.org/10.1016/j.molstruc.2018.04.012

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=186718

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Аганов Альберт Вартанович	ru_RU
dc.contributor.author	Галиуллина Лейсан Фаритовна	ru_RU
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Латфуллин Ильдус Анварович	ru_RU
dc.contributor.author	Мусабирова Гузель Салаватовна	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles // BioNanoScience, V. 6, 2016.-P. 352-354.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=186718	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Nuclear magnetic resonance	ru_RU
dc.subject	Fluvastatin	ru_RU
dc.subject	Micelles	ru_RU
dc.subject	Molecular complex	ru_RU
dc.title	NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU