| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2018 |
| Язык | русский |
|
Галиуллина Лейсан Фаритовна, автор
Клочков Владимир Васильевич, автор
Латфуллин Ильдус Анварович, автор
|
|
Мусабирова Гузель Салаватовна, автор
|
| Библиографическое описание на языке оригинала |
L.F. Galiullina, G.S. Musabirova, I.A. Latfullin, A.V. Aganov, V.V. Klochkov. Spatial structure of atorvastatin and its complex with model membrane in solution studied by NMR and theoretical calculations // Journal of Molecular Structure, V. 1167, 2018.-P.69-77. |
| Аннотация |
Atorvastatin is a drug of the statin group which possesses the ability to decrease low-density lipoprotein cholesterol level by the competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. There is a hypothesis that pharmacological properties of statins depend on their location in the cell membrane. Intermolecular complex of atorvastatin with dodecylphosphocholine (DPC) micelle was investigated by NMR and computational methods. The results of NMR experiments showed that atorvastatin forms molecular complex with model membrane in solution by penetrating a space between
hydrocarbon chains of the DPC micelle. Analysis of obtained data in comparison with previously reported results for simvastatin, pravastatin, fluvastatin and cerivastatin showed that locations of statins in model membranes correlate with their pharmacological features, such as efficacy and risk of rhabdomyolysis. |
| Ключевые слова |
Atorvastatin, Statins, NMR, Nuclear overhauser effect, Dodecylphosphocholine micelles, Molecular complex |
| Название журнала |
JOURNAL OF MOLECULAR STRUCTURE
|
| URL |
http://www.elsevier.com/locate/molstruc |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=186720 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Галиуллина Лейсан Фаритовна |
ru_RU |
| dc.contributor.author |
Клочков Владимир Васильевич |
ru_RU |
| dc.contributor.author |
Латфуллин Ильдус Анварович |
ru_RU |
| dc.contributor.author |
Мусабирова Гузель Салаватовна |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
L.F. Galiullina, G.S. Musabirova, I.A. Latfullin, A.V. Aganov, V.V. Klochkov. Spatial structure of atorvastatin and its complex with model membrane in solution studied by NMR and theoretical calculations // Journal of Molecular Structure, V. 1167, 2018.-P.69-77. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=186720 |
ru_RU |
| dc.description.abstract |
JOURNAL OF MOLECULAR STRUCTURE |
ru_RU |
| dc.description.abstract |
Atorvastatin is a drug of the statin group which possesses the ability to decrease low-density lipoprotein cholesterol level by the competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. There is a hypothesis that pharmacological properties of statins depend on their location in the cell membrane. Intermolecular complex of atorvastatin with dodecylphosphocholine (DPC) micelle was investigated by NMR and computational methods. The results of NMR experiments showed that atorvastatin forms molecular complex with model membrane in solution by penetrating a space between
hydrocarbon chains of the DPC micelle. Analysis of obtained data in comparison with previously reported results for simvastatin, pravastatin, fluvastatin and cerivastatin showed that locations of statins in model membranes correlate with their pharmacological features, such as efficacy and risk of rhabdomyolysis. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Atorvastatin |
ru_RU |
| dc.subject |
Statins |
ru_RU |
| dc.subject |
NMR |
ru_RU |
| dc.subject |
Nuclear overhauser effect |
ru_RU |
| dc.subject |
Dodecylphosphocholine micelles |
ru_RU |
| dc.subject |
Molecular complex |
ru_RU |
| dc.title |
Spatial structure of atorvastatin and its complex with model membrane in solution studied by NMR and theoretical calculations |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
