КФУ. Карточка публикации. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats.

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THE INFLUENCE OF IF-CURRENT BLOCKADE ON THE PARAMETERS OF ACTION POTENTIAL AMONG 1-WEEK AND 20-WEEK-OLD RATS.

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2018

Язык

английский

Авторы, сотрудники КФУ

Зефиров Тимур Львович, автор

Зиятдинова Нафиса Ильгизовна, автор

Фасхутдинов Ленар Ильсурович, автор

Библиографическое описание на языке оригинала

Faskhutdinov L.I. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats. / L.I. Faskhutdinov, N.I. Ziyatdinova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences November–December 2018 RJPBCS 9(6) Page No. 472-478.

Аннотация

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES

Ключевые слова

action potential, action potential duration, the duration at repolarization level of 50%, the duration at repolarization level of 90%,heart, rat

Название журнала

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES

URL

https://www.rjpbcs.com/2018_9.6.html

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https://repository.kpfu.ru/?p_id=188559

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зефиров Тимур Львович	ru_RU
dc.contributor.author	Зиятдинова Нафиса Ильгизовна	ru_RU
dc.contributor.author	Фасхутдинов Ленар Ильсурович	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Faskhutdinov L.I. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats. / L.I. Faskhutdinov, N.I. Ziyatdinova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences November–December 2018 RJPBCS 9(6) Page No. 472-478.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=188559	ru_RU
dc.description.abstract	RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES	ru_RU
dc.description.abstract	RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES	ru_RU
dc.description.abstract	This type of currents participates in slow diastolic depolarization and is considered the sinus-atrial node current. In literary sources, much is said about the fact that If-currents are present in atypical cardiomyocytes. But the information about the role of currents in functional cardiomyocytes during the generation of action potential is scarce. One of the common current blockers activated by hyperpolarization is ZD7288. The results of experiments showed that ZD7288 in concentrations of 10-9 M and 10-8 M did not cause significant changes in action potential parameters. The remaining concentrations cause a significant increase of the action potential duration at the repolarization level of 50%, 90%, and 100%. Consequently, the blockade of currents activated by hyperpolarization causes the increase of the action potential time parameters.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	action potential	ru_RU
dc.subject	action potential duration	ru_RU
dc.subject	the duration at repolarization level of 50%	ru_RU
dc.subject	the duration at repolarization level of 90%	ru_RU
dc.subject	heart	ru_RU
dc.subject	rat	ru_RU
dc.title	The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats.	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU