КФУ. Карточка публикации. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

ETHANOL AND THE DEVELOPING BRAIN: INHIBITION OF NEURONAL ACTIVITY AND NEUROAPOPTOSIS

Форма представления

Российские монографии

Год публикации

2018

Язык

английский

Авторы, сотрудники КФУ

Хазипов Рустем Нариманович, автор

Авторы, аспиранты КФУ

Лотфуллина Наиля Зуфаровна, автор

Библиографическое описание на языке оригинала

Lotfullina N. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis / Lotfullina N, Khazipov R. - Neuroscientist. 2018 Apr;24(2):130-141.

Аннотация

Ethanol induces massive neuroapoptosis in the developing brain. One of the main hypotheses that has been put forward to explain the deleterious actions of ethanol in the immature brain involves an inhibition of neuronal activity. Here, we review recent evidence for this hypothesis obtained in the somatosensory cortex and hippocampus of neonatal rodents. In both structures, ethanol strongly inhibits brain activity. At the doses inducing massive neuroapoptosis, ethanol completely suppresses the early activity patterns of spindle-bursts and gamma oscillations in the neocortex and the early sharp-waves in the hippocampus. The inhibitory effects of ethanol decrease with age and in adult animals, ethanol only mildly depresses neuronal firing and induces delta-wave activity. Suppression of cortical activity in neonatal animals likely involves inhibition of the myoclonic twitches, an important physiological trigger for the early activity bursts, and inhibition of the thalamocortical and intrac

Ключевые слова

ethanol, apoptosis, electroencephalogram, fetal alcohol syndrome, GABA, NMDA

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=188808

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Хазипов Рустем Нариманович	ru_RU
dc.contributor.author	Лотфуллина Наиля Зуфаровна	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Lotfullina N. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis / Lotfullina N, Khazipov R. - Neuroscientist. 2018 Apr;24(2):130-141.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=188808	ru_RU
dc.description.abstract	Ethanol induces massive neuroapoptosis in the developing brain. One of the main hypotheses that has been put forward to explain the deleterious actions of ethanol in the immature brain involves an inhibition of neuronal activity. Here, we review recent evidence for this hypothesis obtained in the somatosensory cortex and hippocampus of neonatal rodents. In both structures, ethanol strongly inhibits brain activity. At the doses inducing massive neuroapoptosis, ethanol completely suppresses the early activity patterns of spindle-bursts and gamma oscillations in the neocortex and the early sharp-waves in the hippocampus. The inhibitory effects of ethanol decrease with age and in adult animals, ethanol only mildly depresses neuronal firing and induces delta-wave activity. Suppression of cortical activity in neonatal animals likely involves inhibition of the myoclonic twitches, an important physiological trigger for the early activity bursts, and inhibition of the thalamocortical and intrac	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ethanol	ru_RU
dc.subject	apoptosis	ru_RU
dc.subject	electroencephalogram	ru_RU
dc.subject	fetal alcohol syndrome	ru_RU
dc.subject	GABA	ru_RU
dc.subject	NMDA	ru_RU
dc.title	Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis	ru_RU
dc.type	Российские монографии	ru_RU