КФУ. Карточка публикации. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation

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NOVEL WATER-SOLUBLE METHANOFULLERENES C 60 [C 13 H 18 O 4 (OH) 4] 6 AND C 60 [C 9 H 10 O 4 (OH) 4] 6: PROMISING UNCOUPLERS OF RESPIRATION AND PHOSPHORYLATION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Калачева Наталия Васильевна, автор

Библиографическое описание на языке оригинала

Kalacheva N. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation / Kalacheva NV, Gubskaya VP, Fazleeva GM, Igtisamova GR, Nuretdinov IA, Rizvanov AA, Cherepnev GV // Bioorganic & medicinal chemistry letters.- 2015.- Vol.25 – P. 5250–5253.

Аннотация

Here, we report for the first time on two novel water-soluble polyol-methanofullerenes which uncouple respiration and oxidative phosphorylation. A cytofluorimetric JC-1-based ratiometric assay was used to quantify mitochondrial potential Wm in Yarrowia lipolytica cells exposed to the fullerenes tested. Both methanofullerenes significantly downregulated Wm, thereby decreasing the subset of cells with high mitochondrial potential compared with intact control cells. The Wm-low subset of Yarrowia lipolytica cells resulted from methanofullerenes exposure preserved physiological cell size and granularity patterns.

Ключевые слова

Water-soluble methanofullerenes Mitochondrial transmembrane potential Uncouplers of oxidative phosphorylation

Название журнала

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

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https://repository.kpfu.ru/?p_id=191442

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Калачева Наталия Васильевна	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Kalacheva N. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation / Kalacheva NV, Gubskaya VP, Fazleeva GM, Igtisamova GR, Nuretdinov IA, Rizvanov AA, Cherepnev GV // Bioorganic & medicinal chemistry letters.- 2015.- Vol.25 – P. 5250–5253.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=191442	ru_RU
dc.description.abstract	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS	ru_RU
dc.description.abstract	Here, we report for the first time on two novel water-soluble polyol-methanofullerenes which uncouple respiration and oxidative phosphorylation. A cytofluorimetric JC-1-based ratiometric assay was used to quantify mitochondrial potential Wm in Yarrowia lipolytica cells exposed to the fullerenes tested. Both methanofullerenes significantly downregulated Wm, thereby decreasing the subset of cells with high mitochondrial potential compared with intact control cells. The Wm-low subset of Yarrowia lipolytica cells resulted from methanofullerenes exposure preserved physiological cell size and granularity patterns.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU