| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2018 |
| Язык | английский |
|
Курбангалиева Альмира Рафаэловна, автор
Сайгитбаталова Елена Шириповна, автор
Танака Кацунори , автор
|
|
Сайгитбаталова Елена Шириповна, автор
|
| Библиографическое описание на языке оригинала |
Tanei, T. Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology / T. Tanei, A. R. Pradipta, K. Morimoto, M. Fujii, M. Arata, A. Ito, M. Yoshida, E. Saigitbatalova, A. Kurbangalieva, J. Ikeda, E. Morii, S. Noguchi, K. Tanaka // Adv. Sci. ? 2018. ? Article № 1801479. |
| Аннотация |
Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A ?click-to-sense? probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy. Using live breast tissues resected from breast cancer patients, it is demonstrated that this method can quickly, selectively, and sensitively differentiate cancer lesion from normal breast gland or benign proliferative lesions. Since acrolein is accumulated in all types of cancers, this method could be used to quickly assess the surgical margins in other types of cancer. |
| Ключевые слова |
Acrolein, breast cancer, "click-to-sense" probe, oxidative stress, fluorescence microscopy |
| Название журнала |
Advanced Science
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057300739&doi=10.1002%2fadvs.201801479&partnerID=40&md5=fc3c552d75cc51d5ff5daa6465de6073 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=191578 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.contributor.author |
Сайгитбаталова Елена Шириповна |
ru_RU |
| dc.contributor.author |
Танака Кацунори |
ru_RU |
| dc.contributor.author |
Сайгитбаталова Елена Шириповна |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
Tanei, T. Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology / T. Tanei, A. R. Pradipta, K. Morimoto, M. Fujii, M. Arata, A. Ito, M. Yoshida, E. Saigitbatalova, A. Kurbangalieva, J. Ikeda, E. Morii, S. Noguchi, K. Tanaka // Adv. Sci. ? 2018. ? Article № 1801479. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=191578 |
ru_RU |
| dc.description.abstract |
Advanced Science |
ru_RU |
| dc.description.abstract |
Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A ?click-to-sense? probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy. Using live breast tissues resected from breast cancer patients, it is demonstrated that this method can quickly, selectively, and sensitively differentiate cancer lesion from normal breast gland or benign proliferative lesions. Since acrolein is accumulated in all types of cancers, this method could be used to quickly assess the surgical margins in other types of cancer. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Acrolein |
ru_RU |
| dc.subject |
breast cancer |
ru_RU |
| dc.subject |
"click-to-sense" probe |
ru_RU |
| dc.subject |
oxidative stress |
ru_RU |
| dc.subject |
fluorescence microscopy |
ru_RU |
| dc.title |
Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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