КФУ. Карточка публикации. Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide

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CONFORMATIONAL VARIABILITY OF CYCLOSPORIN C DISSOLVED IN DIMETHYLFORMAMIDE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2019

Язык

английский

Авторы, сотрудники КФУ

Ефимов Сергей Владимирович, автор

Згадзай Юрий Олегович, автор

Клочков Владимир Васильевич, автор

Авторы, студенты КФУ

Дарвиш Шаза , автор

Библиографическое описание на языке оригинала

Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide / S.V. Efimov, Yu.O. Zgadzay, S. Darwish, V.V. Klochkov // BioNanoScience. - 2019. - Vol. 9, Is. 3. - P. 620-624.

Аннотация

This paper presents characterization of conformational equilibrium of cyclosporin C dissolved in dimethylformamide. High-resolution NMR spectra recorded at 700 MHz allowed distinguishing most of observed amide proton signals. Existence of several intramolecular hydrogen bonds over the whole set of conformers was supposed; in most cases, however, these bonds are disrupted. Kinetics of a conformational transition is evaluated. Obtained results are in agreement with what is known about cyclosporin A, but can give new information on the role of additional H-bond donors (there are six of them in CsC vs. five in CsA) in the observed chain flexibility.

Ключевые слова

dynamic NMR, cyclosporin C, chemical exchange, hydrogen bond

Название журнала

BioNanoScience

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066106117&doi=10.1007%2fs12668-019-00641-z&partnerID=40&md5=cb85cba8236adc0f3df8a093f6c89161

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https://repository.kpfu.ru/?p_id=204648

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ефимов Сергей Владимирович	ru_RU
dc.contributor.author	Згадзай Юрий Олегович	ru_RU
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Дарвиш Шаза	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide / S.V. Efimov, Yu.O. Zgadzay, S. Darwish, V.V. Klochkov // BioNanoScience. - 2019. - Vol. 9, Is. 3. - P. 620-624.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=204648	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	This paper presents characterization of conformational equilibrium of cyclosporin C dissolved in dimethylformamide. High-resolution NMR spectra recorded at 700 MHz allowed distinguishing most of observed amide proton signals. Existence of several intramolecular hydrogen bonds over the whole set of conformers was supposed; in most cases, however, these bonds are disrupted. Kinetics of a conformational transition is evaluated. Obtained results are in agreement with what is known about cyclosporin A, but can give new information on the role of additional H-bond donors (there are six of them in CsC vs. five in CsA) in the observed chain flexibility.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	dynamic NMR	ru_RU
dc.subject	cyclosporin C	ru_RU
dc.subject	chemical exchange	ru_RU
dc.subject	hydrogen bond	ru_RU
dc.title	Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU