КФУ. Карточка публикации. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing

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ISOFORMS OF BASE EXCISION REPAIR ENZYMES PRODUCED BY ALTERNATIVE SPLICING

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2019

Язык

английский

Авторы, сотрудники КФУ

Хайруллин Рафиль Фидаилевич, автор

Другие авторы

Boldinova Elizaveta , автор

Библиографическое описание на языке оригинала

Boldinova, E.O.; Khairullin, R.F.; Makarova, A.V.; Zharkov, D.O. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing. Int. J. Mol. Sci. 2019, 20, 3279.

Аннотация

Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.

Ключевые слова

alternative splicing, DNA glycosylases, apurinic/apyrimidinic endonuclease, DNA polymerase beta

Название журнала

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URL

https://www.mdpi.com/1422-0067/20/13/3279

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https://repository.kpfu.ru/?p_id=205340

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Хайруллин Рафиль Фидаилевич	ru_RU
dc.contributor.author	Boldinova Elizaveta	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Boldinova, E.O.; Khairullin, R.F.; Makarova, A.V.; Zharkov, D.O. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing. Int. J. Mol. Sci. 2019, 20, 3279.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=205340	ru_RU
dc.description.abstract	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	ru_RU
dc.description.abstract	Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	alternative splicing	ru_RU
dc.subject	DNA glycosylases	ru_RU
dc.subject	apurinic/apyrimidinic endonuclease	ru_RU
dc.subject	DNA polymerase beta	ru_RU
dc.title	Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU