КФУ. Карточка публикации. Zeolites as Carriers of Antitumor Ribonuclease Binase

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ZEOLITES AS CARRIERS OF ANTITUMOR RIBONUCLEASE BINASE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2019

Язык

английский

Авторы, сотрудники КФУ

Зеленихин Павел Валерьевич, автор

Ильинская Ольга Николаевна, автор

Лопатин Олег Николаевич, автор

Ходжаева Вера Сергеевна, автор

Библиографическое описание на языке оригинала

Khojaewa V. Zeolites as Carriers of Antitumor Ribonuclease Binase / Khojaewa V, Lopatin O, Zelenikhin P, Ilinskaya O // Front Pharmacol. – 2019. – V.10, P. 442. doi:10.3389/fphar.2019.00442. eCollection 2019.

Аннотация

Natural and synthetic zeolites have many applications in biomedicine and nutrition. Due to its properties, zeolites can absorb therapeutically active proteins and release them under physiological conditions. In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as well as chabazite always demonstrated enhanced toxicity (up to 57 and 60% for clinoptilolite and chabazite, respectively) in comparison with binase and zeolites separately. Our results contribute to the perspective development of binase-based complexes for therapy of colorectal cancer for or the treatment of malignant skin neoplasms where the complexes can be used in pasty form.

Ключевые слова

binase, chabazite, clinoptilolite, cytotoxic RNAse, immobilization, natrolite, zeolites

Название журнала

FRONTIERS IN PHARMACOLOGY

URL

https://www.frontiersin.org/articles/10.3389/fphar.2019.00442/full

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зеленихин Павел Валерьевич	ru_RU
dc.contributor.author	Ильинская Ольга Николаевна	ru_RU
dc.contributor.author	Лопатин Олег Николаевич	ru_RU
dc.contributor.author	Ходжаева Вера Сергеевна	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Khojaewa V. Zeolites as Carriers of Antitumor Ribonuclease Binase / Khojaewa V, Lopatin O, Zelenikhin P, Ilinskaya O // Front Pharmacol. – 2019. – V.10, P. 442. doi:10.3389/fphar.2019.00442. eCollection 2019.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=205905	ru_RU
dc.description.abstract	FRONTIERS IN PHARMACOLOGY	ru_RU
dc.description.abstract	Natural and synthetic zeolites have many applications in biomedicine and nutrition. Due to its properties, zeolites can absorb therapeutically active proteins and release them under physiological conditions. In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as well as chabazite always demonstrated enhanced toxicity (up to 57 and 60% for clinoptilolite and chabazite, respectively) in comparison with binase and zeolites separately. Our results contribute to the perspective development of binase-based complexes for therapy of colorectal cancer for or the treatment of malignant skin neoplasms where the complexes can be used in pasty form.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	binase	ru_RU
dc.subject	chabazite	ru_RU
dc.subject	clinoptilolite	ru_RU
dc.subject	cytotoxic RNAse	ru_RU
dc.subject	immobilization	ru_RU
dc.subject	natrolite	ru_RU
dc.subject	zeolites	ru_RU
dc.title	Zeolites as Carriers of Antitumor Ribonuclease Binase	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU