| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Герасимова Елена Вячеславовна, автор
Закирова Гульшат Фоатовна, автор
Ситдикова Гузель Фаритовна, автор
|
| Библиографическое описание на языке оригинала |
Gaifullina AS, Lazniewska J, Gerasimova EV, Burkhanova GF, Rzhepetskyy Y, Tomin A, Rivas-Ramirez P, Huang J, Cmarko L, Zamponi GW ,Sitdikova GF, Weiss N. A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy. Pain. 2019, 160(12):2798-2810. doi: 10.1097/j.pain.0000000000001669 |
| Аннотация |
Pain |
| Ключевые слова |
homocysteinemia, T-type calcium channels |
| Название журнала |
Pain
|
| URL |
https://www.ncbi.nlm.nih.gov/pubmed/31365467 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=206686 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Герасимова Елена Вячеславовна |
ru_RU |
| dc.contributor.author |
Закирова Гульшат Фоатовна |
ru_RU |
| dc.contributor.author |
Ситдикова Гузель Фаритовна |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Gaifullina AS, Lazniewska J, Gerasimova EV, Burkhanova GF, Rzhepetskyy Y, Tomin A, Rivas-Ramirez P, Huang J, Cmarko L, Zamponi GW ,Sitdikova GF, Weiss N. A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy. Pain. 2019, 160(12):2798-2810. doi: 10.1097/j.pain.0000000000001669 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=206686 |
ru_RU |
| dc.description.abstract |
Pain |
ru_RU |
| dc.description.abstract |
Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on the processing of peripheral nociception have not yet been investigated comprehensively. Here, using a rodent model of experimental homocysteinemia, we report the causal association between homocysteine and the development of mechanical allodynia. Homocysteinemia-induced mechanical allodynia was reversed upon pharmacological inhibition of T-type calcium channels. In addition, our in vitro studies indicate that homocysteine enhances recombinant T-type calcium currents by promoting the recycling of Cav3.2 channels back to the plasma membrane via a PKC-dependent signaling pathway that requires the direct phosphorylation of Cav3.2 at specific loci. Altogether, these results reveal an unrecognized signaling pathway that modulates the expression of T-type calcium channels, and may potentially contribute to the development of peripheral neuropathy associated with homocysteinemia. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
homocysteinemia |
ru_RU |
| dc.subject |
T-type calcium channels |
ru_RU |
| dc.title |
A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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