КФУ. Карточка публикации. DOI 10.1007/s12668-018-0528-1

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DOI 10.1007/S12668-018-0528-1

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2018

Авторы, сотрудники КФУ

Абдулхаков Сайяр Рустамович, автор

Лайков Александр Владимирович, автор

Другие авторы

Зайцева Т.А., Медведева С.Н.

Авторы, аспиранты КФУ

Лопухов Виктор Леонидович, автор

Библиографическое описание на языке оригинала

LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine

Аннотация

The negative impact of tobacco smoke on the human body is due to a wide range of harmful substances including volatile organic compounds (VOCs). Some VOCs of tobacco smoke metabolize in human organism into mercapturic acids (MAs). The determination of the amount of MAs in readily available biological fluids, for example in urine, allows to assess the level of exposure of these VOCs in a particular person. It is useful to assess the impact of individual VOCs on the body together with the assessment of the intake of nicotine. The intake of nicotine can be determined by the content of its metabolites in the urine, in particular by the content of trans-3′-hydroxycotinine (tH-Cot). A joint assessment of the concentrations of trans-3′-hydroxycotinine and MAs in urine allows obtaining selective information about effects of different VOCs and nicotine on the smoker?s body. We have developed a liquid chromatography?mass spectrometry (LC-MS) method for simultaneous quantifying of tH-Cot

Ключевые слова

Mercapturic acids, Nicotine, Tobacco, LC-MS

Название журнала

BioNanoScience

URL

https://link.springer.com/article/10.1007%2Fs12668-018-0528-1

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https://repository.kpfu.ru/?p_id=211141

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абдулхаков Сайяр Рустамович	ru_RU
dc.contributor.author	Лайков Александр Владимирович	ru_RU
dc.contributor.author	Лопухов Виктор Леонидович	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=211141	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The negative impact of tobacco smoke on the human body is due to a wide range of harmful substances including volatile organic compounds (VOCs). Some VOCs of tobacco smoke metabolize in human organism into mercapturic acids (MAs). The determination of the amount of MAs in readily available biological fluids, for example in urine, allows to assess the level of exposure of these VOCs in a particular person. It is useful to assess the impact of individual VOCs on the body together with the assessment of the intake of nicotine. The intake of nicotine can be determined by the content of its metabolites in the urine, in particular by the content of trans-3′-hydroxycotinine (tH-Cot). A joint assessment of the concentrations of trans-3′-hydroxycotinine and MAs in urine allows obtaining selective information about effects of different VOCs and nicotine on the smoker?s body. We have developed a liquid chromatography?mass spectrometry (LC-MS) method for simultaneous quantifying of tH-Cot	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Mercapturic acids	ru_RU
dc.subject	Nicotine	ru_RU
dc.subject	Tobacco	ru_RU
dc.subject	LC-MS	ru_RU
dc.title	DOI 10.1007/s12668-018-0528-1	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU