| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Богданов Михаил Васильевич, автор
Булатова Лейсан Фаридовна, автор
Ионова Наталия Эрнестовна, автор
Киямова Рамзия Галлямовна, автор
Скрипова Вера Сергеевна, автор
|
|
Решетникова Дарья Дмитриевна, автор
|
| Библиографическое описание на языке оригинала |
L. Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation // Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130. |
| Аннотация |
Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and hypoxia on the model of Na-dependent phosphate-cotransporter NaPi2b. NaPi2b (SLC34A2, NaPi-IIb, NPT2b) belongs to the SLC34A2 transporters family and is involved in maintaining phosphate homeostasis in the human body. NaPi2b express in a number of normal and malignant tissues, including ovarian, breast and triple-negative breast cancer. It is an integral membrane protein with a large extramembrane domain 4 (EMD4, 234-362 aa), 8 transmembrane domains, N - and C - ends located in the cytoplasm. |
| Ключевые слова |
NaPi2b, folding, cancer |
| Название журнала |
ANNALS OF ONCOLOGY
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=216999 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Богданов Михаил Васильевич |
ru_RU |
| dc.contributor.author |
Булатова Лейсан Фаридовна |
ru_RU |
| dc.contributor.author |
Ионова Наталия Эрнестовна |
ru_RU |
| dc.contributor.author |
Киямова Рамзия Галлямовна |
ru_RU |
| dc.contributor.author |
Скрипова Вера Сергеевна |
ru_RU |
| dc.contributor.author |
Решетникова Дарья Дмитриевна |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
L. Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation // Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=216999 |
ru_RU |
| dc.description.abstract |
ANNALS OF ONCOLOGY |
ru_RU |
| dc.description.abstract |
Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and hypoxia on the model of Na-dependent phosphate-cotransporter NaPi2b. NaPi2b (SLC34A2, NaPi-IIb, NPT2b) belongs to the SLC34A2 transporters family and is involved in maintaining phosphate homeostasis in the human body. NaPi2b express in a number of normal and malignant tissues, including ovarian, breast and triple-negative breast cancer. It is an integral membrane protein with a large extramembrane domain 4 (EMD4, 234-362 aa), 8 transmembrane domains, N - and C - ends located in the cytoplasm. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
NaPi2b |
ru_RU |
| dc.subject |
folding |
ru_RU |
| dc.subject |
cancer |
ru_RU |
| dc.title |
Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
