| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2020 |
| Язык | английский |
|
Зиятдинова Гузель Камилевна, автор
|
|
Арсеньев Максим Вячеславович, автор
Богданов Андрей Владимирович, автор
Бухаров Сергей Владимирович, автор
Волошина Александра Дмитриевна, автор
Исхакова Камилла Равилевна, автор
Кулик Наталия Владимировна, автор
Сапунова Анастасия Сергеевна, автор
Терехова Наталия Викторовна, автор
|
| Библиографическое описание на языке оригинала |
Bogdanov, A.V. Ammonium‐charged sterically hindered phenols with antioxidant and selective anti‐gram‐positive bacterial activity / A.V. Bogdanov, K.R. Iskhakova, A.D. Voloshina, A.S. Sapunova, N.V. Kulik, N.V. Terekhova, M.V. Arsenyev, G.K. Ziyatdinova, S.V. Bucharov // Chem. Biodiversity. – 2020. – V. 17. – № 5. – Article e2000147. – 8 p. |
| Аннотация |
The increase in the resistance of pathogens, in particular Staphylococcus aureus , to the action of antibiotics necessitates the search for new readily available and non‐toxic drugs. In solving this problem, phenolic acylhydrazones have high potential. In this communication, the synthesis of quaternary ammonium compounds containing a differently substituted phenolic moiety has been performed. An initial study of antimicrobial activity showed that these compounds are highly selective against S. aureus and B. cereus . The highest activity (MIC 2.0 μm ) was shown by hydrazones containing a catechol fragment. These compounds are more than 3‐fold more active against S. aureus and 3–10‐fold more active against B. cereus than norfloxacin. Low hemolytic and high antioxidant activities of all new compounds were also established. |
| Ключевые слова |
Hydrazones, cell membrane permeability, antimicrobial activity, antioxidant activity, hemolytic activity |
| Название журнала |
Chemistry and Biodiversity
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083973311&doi=10.1002%2fcbdv.202000147&partnerID=40&md5=bdafd5efb6cb57cd5e211c627d189b34 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=232630 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зиятдинова Гузель Камилевна |
ru_RU |
| dc.contributor.author |
Арсеньев Максим Вячеславович |
ru_RU |
| dc.contributor.author |
Богданов Андрей Владимирович |
ru_RU |
| dc.contributor.author |
Бухаров Сергей Владимирович |
ru_RU |
| dc.contributor.author |
Волошина Александра Дмитриевна |
ru_RU |
| dc.contributor.author |
Исхакова Камилла Равилевна |
ru_RU |
| dc.contributor.author |
Кулик Наталия Владимировна |
ru_RU |
| dc.contributor.author |
Сапунова Анастасия Сергеевна |
ru_RU |
| dc.contributor.author |
Терехова Наталия Викторовна |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Bogdanov, A.V. Ammonium‐charged sterically hindered phenols with antioxidant and selective anti‐gram‐positive bacterial activity / A.V. Bogdanov, K.R. Iskhakova, A.D. Voloshina, A.S. Sapunova, N.V. Kulik, N.V. Terekhova, M.V. Arsenyev, G.K. Ziyatdinova, S.V. Bucharov // Chem. Biodiversity. – 2020. – V. 17. – № 5. – Article e2000147. – 8 p. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=232630 |
ru_RU |
| dc.description.abstract |
Chemistry and Biodiversity |
ru_RU |
| dc.description.abstract |
The increase in the resistance of pathogens, in particular Staphylococcus aureus , to the action of antibiotics necessitates the search for new readily available and non‐toxic drugs. In solving this problem, phenolic acylhydrazones have high potential. In this communication, the synthesis of quaternary ammonium compounds containing a differently substituted phenolic moiety has been performed. An initial study of antimicrobial activity showed that these compounds are highly selective against S. aureus and B. cereus . The highest activity (MIC 2.0 μm ) was shown by hydrazones containing a catechol fragment. These compounds are more than 3‐fold more active against S. aureus and 3–10‐fold more active against B. cereus than norfloxacin. Low hemolytic and high antioxidant activities of all new compounds were also established. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Hydrazones |
ru_RU |
| dc.subject |
cell membrane permeability |
ru_RU |
| dc.subject |
antimicrobial activity |
ru_RU |
| dc.subject |
antioxidant activity |
ru_RU |
| dc.subject |
hemolytic activity |
ru_RU |
| dc.title |
Ammonium-Charged Sterically Hindered Phenols with Antioxidant and Selective Anti-Gram-Positive Bacterial Activity |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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