КФУ. Карточка публикации. Development of Novel Effective Agents Against Candida albicans Biofilms

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DEVELOPMENT OF NOVEL EFFECTIVE AGENTS AGAINST CANDIDA ALBICANS BIOFILMS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2019

Язык

русский

Авторы, сотрудники КФУ

Павельев Роман Сергеевич, автор

Библиографическое описание на языке оригинала

Nikitina L.E. Development of Novel Effective Agents Against Candida albicans Biofilms / L.E. Nikitina, S.А. Lisovskaya, V.A. Startseva, R.S. Pavelyev, I.R. Gilfanov, I.V. Fedyunina, O.V. Ostolopovskaya, R.F. Akhverdiev // BioNanoScience – 2019. – V 9 (3). – P.539-544.

Аннотация

It is common knowledge that Candida albicans are one of the main sources of fungal infections which may lead to inflammation or even threaten life. Until now, fungal infection treatment has been considered as a challenging task due to several problems associated with their application like toxicity, drug interactions, and resistance. This paper outlines a new approach to develop effective agents against Candida albicans biofilms. The impact of borneols and sulfur-containing terpenoids of bornane series on the in vitro formation and growth of clinical strain of C. albicans in biofilms has been studied and compared with modern antimycotics. As a result, thioterpenoid 4 minimum inhibitory concentrations for C. albicans strain plankton ranged from 100 to 200 μg/ml where biofilm growth inhibition occurred at the concentration of 200 μg/ml. It is generally accepted that fluconazole 7 is widely used in clinical practice but still not effective against biofilms of C. albicans fungi. Therefore, we believe that isoborneol 2 and thioterpenoids 3 and 4, as well as terbinafine 6, can be promising starting points for the development of new antifungal agents against the pathogenic activity of fungi including pathogens embedded in biofilms since they demonstrated an effective resistance against the formation of pseudomycelia.

Ключевые слова

Candida albicans, Biofilms, Antifungal activity, Monoterpenoids

Название журнала

BioNanoScience

URL

https://link.springer.com/article/10.1007%2Fs12668-019-00648-6

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https://repository.kpfu.ru/?p_id=233318

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Павельев Роман Сергеевич	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Nikitina L.E. Development of Novel Effective Agents Against Candida albicans Biofilms / L.E. Nikitina, S.А. Lisovskaya, V.A. Startseva, R.S. Pavelyev, I.R. Gilfanov, I.V. Fedyunina, O.V. Ostolopovskaya, R.F. Akhverdiev // BioNanoScience – 2019. – V 9 (3). – P.539-544.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=233318	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	It is common knowledge that Candida albicans are one of the main sources of fungal infections which may lead to inflammation or even threaten life. Until now, fungal infection treatment has been considered as a challenging task due to several problems associated with their application like toxicity, drug interactions, and resistance. This paper outlines a new approach to develop effective agents against Candida albicans biofilms. The impact of borneols and sulfur-containing terpenoids of bornane series on the in vitro formation and growth of clinical strain of C. albicans in biofilms has been studied and compared with modern antimycotics. As a result, thioterpenoid 4 minimum inhibitory concentrations for C. albicans strain plankton ranged from 100 to 200 μg/ml where biofilm growth inhibition occurred at the concentration of 200 μg/ml. It is generally accepted that fluconazole 7 is widely used in clinical practice but still not effective against biofilms of C. albicans fungi. Therefore, we believe that isoborneol 2 and thioterpenoids 3 and 4, as well as terbinafine 6, can be promising starting points for the development of new antifungal agents against the pathogenic activity of fungi including pathogens embedded in biofilms since they demonstrated an effective resistance against the formation of pseudomycelia.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Candida albicans	ru_RU
dc.subject	Biofilms	ru_RU
dc.subject	Antifungal activity	ru_RU
dc.subject	Monoterpenoids	ru_RU
dc.title	Development of Novel Effective Agents Against Candida albicans Biofilms	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU