| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2020 |
| Язык | английский |
|
Сальников Вадим Владимирович, автор
|
|
Зуев Юрий Федорович, автор
|
| Библиографическое описание на языке оригинала |
Dzhigangir Faizullin, Yuliya Valiullina, Vadim Salnikov, , Yuriy Zuev. Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. Nanomedicine: Nanotechnology, Biology, and Medicine
23 (2020) |
| Аннотация |
Extensive studies revealed the role of blood lipid microparticles (liposomes, microvesicles) in activation of coagulation cascade. The
direct interaction of fibrinogen/fibrin with lipid surfaces and its consequence for hemostasis received much less attention. We observed
pronounced changes in both clot morphology and kinetics of fibrin clotting in the presence of artificial liposomes. The evidence was obtained
that lipid microparticles per se present a diffusion barrier to the three-dimensional fibril assembling and pose spatial restrictions for fiber
elongation. On the other hand, fibrinogen adsorption results in its high local concentration on liposome surface that accelerates fibrin
polymerization. Adsorption induces Fg secondary structure alterations which may contribute to the abnormal clot morphology. In
dependence on lipid composition and size of microparticles, the interplay of all the outlined mechanisms determines functionally important
changes of clot morphology. The obtained results contribute to the knowledge of clotting mechanisms in the presence of artificial and natural
lipid microparticles. |
| Ключевые слова |
Liposomes; Fibrinogen; Adsorption; Fibrin clotting |
| Название журнала |
Nanomedicine
|
| URL |
https://www.sciencedirect.com/science/article/pii/S1549963419301820 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=236722 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Сальников Вадим Владимирович |
ru_RU |
| dc.contributor.author |
Зуев Юрий Федорович |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Dzhigangir Faizullin, Yuliya Valiullina, Vadim Salnikov, , Yuriy Zuev. Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. Nanomedicine: Nanotechnology, Biology, and Medicine
23 (2020) |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=236722 |
ru_RU |
| dc.description.abstract |
Nanomedicine |
ru_RU |
| dc.description.abstract |
Extensive studies revealed the role of blood lipid microparticles (liposomes, microvesicles) in activation of coagulation cascade. The
direct interaction of fibrinogen/fibrin with lipid surfaces and its consequence for hemostasis received much less attention. We observed
pronounced changes in both clot morphology and kinetics of fibrin clotting in the presence of artificial liposomes. The evidence was obtained
that lipid microparticles per se present a diffusion barrier to the three-dimensional fibril assembling and pose spatial restrictions for fiber
elongation. On the other hand, fibrinogen adsorption results in its high local concentration on liposome surface that accelerates fibrin
polymerization. Adsorption induces Fg secondary structure alterations which may contribute to the abnormal clot morphology. In
dependence on lipid composition and size of microparticles, the interplay of all the outlined mechanisms determines functionally important
changes of clot morphology. The obtained results contribute to the knowledge of clotting mechanisms in the presence of artificial and natural
lipid microparticles. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
