КФУ. Карточка публикации. Antibacterial activity profile of miramistin in in vitro and in vivo models

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ANTIBACTERIAL ACTIVITY PROFILE OF MIRAMISTIN IN IN VITRO AND IN VIVO MODELS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Агафонова Мария Николаевна, автор

Балакин Константин Валерьевич, автор

Казакова Рената Рувшановна, автор

Никитина Елена Владимировна, автор

Штырлин Юрий Григорьевич, автор

Другие авторы

Любина Анна Павловна, автор

Библиографическое описание на языке оригинала

M.N. Agafonova, R.R. Kazakova, A.P. Lubina, M.I. Zeldi, E.V. Nikitina, K.V. Balakin, Y.G. Shtyrlin. Antibacterial activity profile of miramistin in in vitro and in vivo models // Microb. Pathog. – Vol. 142. – 2020. – P.1-7. https://doi.org/10.1016/j.micpath.2020.104072.

Аннотация

This paper represents a systematic study of antibacterial properties of miramistin. Another objective of this work is to evaluate and compare the exploratory performance of in vitro and in vivo protocols of antiseptics' efficacy testing using miramistin as the reference antiseptic. The results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics' efficacy testing and surface disinfection procedures.

Ключевые слова

Key words: miramistin, minimal inhibitory concentration, minimal bactericidal concentration, suspension test, metal surface test, in vivo rat skin model.

Название журнала

Microbial Pathogenesis

URL

https://doi.org/10.1016/j.micpath.2020.104072.

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https://repository.kpfu.ru/?p_id=236864

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Агафонова Мария Николаевна	ru_RU
dc.contributor.author	Балакин Константин Валерьевич	ru_RU
dc.contributor.author	Казакова Рената Рувшановна	ru_RU
dc.contributor.author	Никитина Елена Владимировна	ru_RU
dc.contributor.author	Штырлин Юрий Григорьевич	ru_RU
dc.contributor.author	Любина Анна Павловна	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	M.N. Agafonova, R.R. Kazakova, A.P. Lubina, M.I. Zeldi, E.V. Nikitina, K.V. Balakin, Y.G. Shtyrlin. Antibacterial activity profile of miramistin in in vitro and in vivo models // Microb. Pathog. – Vol. 142. – 2020. – P.1-7. https://doi.org/10.1016/j.micpath.2020.104072.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=236864	ru_RU
dc.description.abstract	Microbial Pathogenesis	ru_RU
dc.description.abstract	This paper represents a systematic study of antibacterial properties of miramistin. Another objective of this work is to evaluate and compare the exploratory performance of in vitro and in vivo protocols of antiseptics' efficacy testing using miramistin as the reference antiseptic. The results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics' efficacy testing and surface disinfection procedures.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Key words: miramistin	ru_RU
dc.subject	minimal inhibitory concentration	ru_RU
dc.subject	minimal bactericidal concentration	ru_RU
dc.subject	suspension test	ru_RU
dc.subject	metal surface test	ru_RU
dc.subject	in vivo rat skin model.	ru_RU
dc.title	Antibacterial activity profile of miramistin in in vitro and in vivo models	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU