КФУ. Карточка публикации. Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

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HYDROGEN SULFIDE ALLEVIATES ANXIETY, MOTOR, AND COGNITIVE DYSFUNCTIONS IN RATS WITH MATERNAL HYPERHOMOCYSTEINEMIA VIA MITIGATION OF OXIDATIVE STRESS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Богатова Ксения Сергеевна, автор

Герасимова Елена Вячеславовна, автор

Зиятдинова Гузель Камилевна, автор

Ситдикова Гузель Фаритовна, автор

Яковлев Алексей Валерьевич, автор

Яковлева Ольга Владиславовна, автор

Другие авторы

Hermann Anton , автор

Авторы, аспиранты КФУ

Шахматова Виктория Игоревна, автор

Авторы, студенты КФУ

Богатова Ксения Сергеевна, автор

Мухтарова Рената Алмазовна, автор

Библиографическое описание на языке оригинала

Yakovleva, O. Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress / O. Yakovleva, K. Bogatova, R. Mukhtarova, A. Yakovlev, V. Shakhmatova, E. Gerasimova, G. Ziyatdinova, A. Hermann, G. Sitdikova // Biomolecules. - 2020. - V. 10. - № 7. - Article 995. - 23 p.

Аннотация

Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative stress. We analyzed the effects of the H2S donor-sodium hydrosulfide (NaHS) administered to female rats with hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative stress of their offspring. Rats born from females fed with control or high methionine diet, with or without H2S donor injections were investigated. Rats with maternal hHcy exhibit increased levels of total locomotor activity and anxiety, decreased muscle endurance and motor coordination, abnormalities of fine motor control, as well as reduced spatial memory and learning. Oxidative stress in brain tissues measured by activity of glutathione peroxidases and the level of malondialdehyde was higher in rats with maternal hHcy. Concentrations of H2S and the activity and expression of the H2S generating enzyme-cystathionine-beta synthase-were lower compared to the control group. Administration of the H2S donor to females with hHcy during pregnancy prevented behavioral alterations and oxidative stress of their offspring. The acquisition of behavioral together with biochemical studies will add to our knowledge about homocysteine neurotoxicity and proposes H2S as a potential agent for therapy of hHcy associated disorders.

Ключевые слова

hydrogen sulfide (H2S), maternal hyperhomocysteinemia (hHcy), locomotor activity, anxiety, learning and memory, motor dysfunction, H2S production, oxidative stress

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087710864&doi=10.3390%2fbiom10070995&partnerID=40&md5=a921a4fcc778dc3925eb8e3bea41ed32

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https://repository.kpfu.ru/?p_id=237031

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Богатова Ксения Сергеевна	ru_RU
dc.contributor.author	Герасимова Елена Вячеславовна	ru_RU
dc.contributor.author	Зиятдинова Гузель Камилевна	ru_RU
dc.contributor.author	Ситдикова Гузель Фаритовна	ru_RU
dc.contributor.author	Яковлев Алексей Валерьевич	ru_RU
dc.contributor.author	Яковлева Ольга Владиславовна	ru_RU
dc.contributor.author	Hermann Anton	ru_RU
dc.contributor.author	Богатова Ксения Сергеевна	ru_RU
dc.contributor.author	Мухтарова Рената Алмазовна	ru_RU
dc.contributor.author	Шахматова Виктория Игоревна	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Yakovleva, O. Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress / O. Yakovleva, K. Bogatova, R. Mukhtarova, A. Yakovlev, V. Shakhmatova, E. Gerasimova, G. Ziyatdinova, A. Hermann, G. Sitdikova // Biomolecules. - 2020. - V. 10. - № 7. - Article 995. - 23 p.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=237031	ru_RU
dc.description.abstract	Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative stress. We analyzed the effects of the H2S donor-sodium hydrosulfide (NaHS) administered to female rats with hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative stress of their offspring. Rats born from females fed with control or high methionine diet, with or without H2S donor injections were investigated. Rats with maternal hHcy exhibit increased levels of total locomotor activity and anxiety, decreased muscle endurance and motor coordination, abnormalities of fine motor control, as well as reduced spatial memory and learning. Oxidative stress in brain tissues measured by activity of glutathione peroxidases and the level of malondialdehyde was higher in rats with maternal hHcy. Concentrations of H2S and the activity and expression of the H2S generating enzyme-cystathionine-beta synthase-were lower compared to the control group. Administration of the H2S donor to females with hHcy during pregnancy prevented behavioral alterations and oxidative stress of their offspring. The acquisition of behavioral together with biochemical studies will add to our knowledge about homocysteine neurotoxicity and proposes H2S as a potential agent for therapy of hHcy associated disorders.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hydrogen sulfide (H2S)	ru_RU
dc.subject	maternal hyperhomocysteinemia (hHcy)	ru_RU
dc.subject	locomotor activity	ru_RU
dc.subject	anxiety	ru_RU
dc.subject	learning and memory	ru_RU
dc.subject	motor dysfunction	ru_RU
dc.subject	H2S production	ru_RU
dc.subject	oxidative stress	ru_RU
dc.title	Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU