| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2021 |
| Язык | английский |
|
Булатов Эмиль Рафаэлевич, автор
Бумбер Янис Алексеевич, автор
Серебрийский Илья Генрихович, автор
Топчу Юлия Алексеевна, автор
|
|
Мазитова Александра Маратовна, автор
|
| Библиографическое описание на языке оригинала |
Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571 (Q1 SJR 0,740 IF 3.119) |
| Аннотация |
Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents. |
| Ключевые слова |
Design, synthesis, and biological, 2-quinolyl-1,3-tropolon, anti-cancer agents |
| Название журнала |
RSC Advances
|
| URL |
https://pubs.rsc.org/en/content/articlelanding/2021/ra/d0ra10610k#!divAbstract |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=246347 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Булатов Эмиль Рафаэлевич |
ru_RU |
| dc.contributor.author |
Бумбер Янис Алексеевич |
ru_RU |
| dc.contributor.author |
Серебрийский Илья Генрихович |
ru_RU |
| dc.contributor.author |
Топчу Юлия Алексеевна |
ru_RU |
| dc.contributor.author |
Мазитова Александра Маратовна |
ru_RU |
| dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2021 |
ru_RU |
| dc.identifier.citation |
Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571 (Q1 SJR 0,740 IF 3.119) |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=246347 |
ru_RU |
| dc.description.abstract |
RSC Advances |
ru_RU |
| dc.description.abstract |
Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Design |
ru_RU |
| dc.subject |
synthesis |
ru_RU |
| dc.subject |
and biological |
ru_RU |
| dc.subject |
2-quinolyl-1 |
ru_RU |
| dc.subject |
3-tropolon |
ru_RU |
| dc.subject |
anti-cancer agents |
ru_RU |
| dc.title |
Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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