КФУ. Карточка публикации. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-QUINOLYL-1,3-TROPOLONE DERIVATIVES AS NEW ANTI-CANCER AGENTS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

английский

Авторы, сотрудники КФУ

Абрамова Зинаида Ивановна, автор

Булатов Эмиль Рафаэлевич, автор

Бумбер Янис Алексеевич, автор

Серебрийский Илья Генрихович, автор

Топчу Юлия Алексеевна, автор

Усак Мухаммет , автор

Авторы, аспиранты КФУ

Мазитова Александра Маратовна, автор

Библиографическое описание на языке оригинала

Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571(Q1 IF3.119)

Аннотация

biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.

Ключевые слова

Design, synthesis, and biological, 2-quinolyl-1,3-tropolon, anti-cancer agents

Название журнала

RSC Advances

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100133501&doi=10.1039%2fd0ra10610k&partnerID=40&md5=d4fd3935525b6f2447cb01f1ebbd4ac8

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=249941

Файлы ресурса

Название файла	Размер (Мб)	Формат
F_RSC_Advances_2021.pdf	1,56	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абрамова Зинаида Ивановна	ru_RU
dc.contributor.author	Булатов Эмиль Рафаэлевич	ru_RU
dc.contributor.author	Бумбер Янис Алексеевич	ru_RU
dc.contributor.author	Серебрийский Илья Генрихович	ru_RU
dc.contributor.author	Топчу Юлия Алексеевна	ru_RU
dc.contributor.author	Усак Мухаммет	ru_RU
dc.contributor.author	Усак Мухаммет	ru_RU
dc.contributor.author	Мазитова Александра Маратовна	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571(Q1 IF3.119)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=249941	ru_RU
dc.description.abstract	RSC Advances	ru_RU
dc.description.abstract	biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Design	ru_RU
dc.subject	synthesis	ru_RU
dc.subject	and biological	ru_RU
dc.subject	2-quinolyl-1	ru_RU
dc.subject	3-tropolon	ru_RU
dc.subject	anti-cancer agents	ru_RU
dc.title	Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU