КФУ. Карточка публикации. Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

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SYNTHESIS AND IN VITRO EVALUATION OF TRIPHENYLPHOSPHONIUM DERIVATIVES OF ACETYLSALICYLIC AND SALICYLIC ACIDS: STRUCTURE-DEPENDENT INTERACTIONS WITH CANCER CELLS, BACTERIA, AND MITOCHONDRIA

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

английский

Авторы, сотрудники КФУ

Ишкаева Резеда Анасовна, автор

Немтарев Андрей Владимирович, автор

Библиографическое описание на языке оригинала

Tsepaeva O.V, Salikhova T.I, Grigor'eva L.R, D.V. Ponomaryov, T. Dang, R.A. Ishkaeva, T.I. Abdullin, A. Nemtarev, V.F. Mironov.Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria//Medicinal Chemistry Research. - 2021. - Vol.30, Is.4, P. 925-939.

Аннотация

Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP) group was proposed. A series of SA and ASA conjugates linked with the TPP group via alkyl chain linker (C3-C10) was synthesized.

Ключевые слова

Acetylsalicylic acid, anticancer activity, anticancer activity, mitochondrial potential, phosphonium salts, salicylic acid

Название журнала

Medicinal Chemistry Research

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099585446&doi=10.1007%2fs00044-020-02674-6&partnerID=40&md5=1627c1b25d48e80070e773c155ce90cb

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https://repository.kpfu.ru/?p_id=256887

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ишкаева Резеда Анасовна	ru_RU
dc.contributor.author	Немтарев Андрей Владимирович	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Tsepaeva O.V, Salikhova T.I, Grigor'eva L.R, D.V. Ponomaryov, T. Dang, R.A. Ishkaeva, T.I. Abdullin, A. Nemtarev, V.F. Mironov.Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria//Medicinal Chemistry Research. - 2021. - Vol.30, Is.4, P. 925-939.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=256887	ru_RU
dc.description.abstract	Medicinal Chemistry Research	ru_RU
dc.description.abstract	Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP) group was proposed. A series of SA and ASA conjugates linked with the TPP group via alkyl chain linker (C3-C10) was synthesized.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acetylsalicylic acid	ru_RU
dc.subject	anticancer activity	ru_RU
dc.subject	anticancer activity	ru_RU
dc.subject	mitochondrial potential	ru_RU
dc.subject	phosphonium salts	ru_RU
dc.subject	salicylic acid	ru_RU
dc.title	Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU