| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | английский |
|
Байчурина Ирина Алексеевна, автор
Мухамедшина Яна Олеговна, автор
Ризванов Альберт Анатольевич, автор
|
|
James Victoria , автор
Валиуллин Виктор Владимирович, автор
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| Библиографическое описание на языке оригинала |
Baichurina I. et al. The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions/ I. Baichurina ,V. Valiullin ,V. James ,A. Rizvanov,Y. Mukhamedshina //International journal of molecular sciences; 2022. – Т. 23. – №. 1. – С. 114. |
| Аннотация |
International journal of molecular sciences |
| Ключевые слова |
neurological disorders; spinal cord injury; neurodegenerative diseases; miRNA; cerebrospinal fluid; biomarkers |
| Название журнала |
International journal of molecular sciences
|
| Ссылка для РПД |
http://dspace.kpfu.ru/xmlui/bitstream/handle/net/166602/F_ijms_23_00114_v2.pdf?sequence=1&isAllowed=y
|
| URL |
https://www.mdpi.com/1422-0067/23/1/114 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=261957 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Байчурина Ирина Алексеевна |
ru_RU |
| dc.contributor.author |
Мухамедшина Яна Олеговна |
ru_RU |
| dc.contributor.author |
Ризванов Альберт Анатольевич |
ru_RU |
| dc.contributor.author |
James Victoria |
ru_RU |
| dc.contributor.author |
Валиуллин Виктор Владимирович |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Baichurina I. et al. The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions/ I. Baichurina ,V. Valiullin ,V. James ,A. Rizvanov,Y. Mukhamedshina //International journal of molecular sciences; 2022. – Т. 23. – №. 1. – С. 114. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=261957 |
ru_RU |
| dc.description.abstract |
International journal of molecular sciences |
ru_RU |
| dc.description.abstract |
Despite extensive research on neurological disorders, unanswered questions remain regarding the molecular mechanisms underpinning the course of these diseases, and the search continues for effective biomarkers for early diagnosis, prognosis, or therapeutic intervention. These questions are especially acute in the study of spinal cord injury (SCI) and neurodegenerative diseases. It is believed that the changes in gene expression associated with processes triggered by neurological disorders are the result of post-transcriptional gene regulation. microRNAs (miRNAs) are key regulators of post-transcriptional gene expression and, as such, are often looked to in the search for effective biomarkers. We propose that cerebrospinal fluid (CSF) is potentially a source of biomarkers since it is in direct contact with the central nervous system and therefore may contain biomarkers indicating neurodegeneration or damage to the brain and spinal cord. However, since the abundance of miRNAs in CSF is low, their isolation and detection is technically difficult. In this review, we evaluate the findings of recent studies of CSF miRNAs as biomarkers of spinal cord injury (SCI) and neurodegenerative diseases. We also summarize the current knowledge concerning the methods of studying miRNA in CSF, including RNA isolation and normalization of the data, highlighting the caveats of these approaches and possible solutions. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
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ru_RU |
| dc.title |
The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
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