КФУ. Карточка публикации. Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity

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BLOOD SERUM CYTOKINES IN PATIENTS WITH SUBACUTE SPINAL CORD INJURY: A PILOT STUDY TO SEARCH FOR BIOMARKERS OF INJURY SEVERITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Авторы, сотрудники КФУ

Байчурина Ирина Алексеевна, автор

Гаранина Екатерина Евгеньевна, автор

Костенников Александр Александрович, автор

Масгутова Галина Андреевна, автор

Мухамедшина Яна Олеговна, автор

Огурцов Сергей Васильевич, автор

Ризванов Альберт Анатольевич, автор

Шульман Илья Александрович, автор

Другие авторы

Кузнецов Максим Сергеевич, James Victoria

Авторы, аспиранты КФУ

Байчурина Ирина Алексеевна, автор

Костенников Александр Александрович, автор

Сабиров Давран Худайшукурович, автор

Библиографическое описание на языке оригинала

Ogurcov Sergei, Iliya Shulman, Ekaterina Garanina, Davran Sabirov, Irina Baichurina, Maxim Kuznetcov, Galina Masgutova, Alexander Kostennikov, Albert Rizvanov, Victoria James, and Yana Mukhamedshina. 2021. "Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity" Brain Sciences 11, no. 3: 322. https://doi.org/10.3390/brainsci11030322

Аннотация

Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing research into the fundamental processes of neuroinflammatory and autoimmune reactions in SCI, identifying changes in the expression of cytokines. Methods. In this pilot study, an extended multiplex analysis of the cytokine profiles in the serum of patients at 2 weeks post-SCI (n = 28) was carried out, together with an additional assessment of neuron-specific enolase (NSE) and vascular endothelial growth factor (VEGF) levels by enzyme-linked immunosorbent assay. A total of 16 uninjured subjects were enrolled as controls. Results. The data obtained showed a large elevation of IFNγ (>52 fold), CCL27 (>13 fold), and CCL26 (>8 fold) 2 weeks after SCI. The levels of cytokines CXCL5, CCL11, CXCL11, IL10, TNFα, and MIF were different between patients with basel

Ключевые слова

traumatic spinal cord injury; cytokine profile; inflammation; blood serum; clinical trial

Название журнала

Brain Sciences

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https://repository.kpfu.ru/?p_id=265434

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Байчурина Ирина Алексеевна	ru_RU
dc.contributor.author	Гаранина Екатерина Евгеньевна	ru_RU
dc.contributor.author	Костенников Александр Александрович	ru_RU
dc.contributor.author	Масгутова Галина Андреевна	ru_RU
dc.contributor.author	Мухамедшина Яна Олеговна	ru_RU
dc.contributor.author	Огурцов Сергей Васильевич	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Шульман Илья Александрович	ru_RU
dc.contributor.author	Байчурина Ирина Алексеевна	ru_RU
dc.contributor.author	Костенников Александр Александрович	ru_RU
dc.contributor.author	Сабиров Давран Худайшукурович	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Ogurcov Sergei, Iliya Shulman, Ekaterina Garanina, Davran Sabirov, Irina Baichurina, Maxim Kuznetcov, Galina Masgutova, Alexander Kostennikov, Albert Rizvanov, Victoria James, and Yana Mukhamedshina. 2021. "Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity" Brain Sciences 11, no. 3: 322. https://doi.org/10.3390/brainsci11030322	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=265434	ru_RU
dc.description.abstract	Brain Sciences	ru_RU
dc.description.abstract	Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing research into the fundamental processes of neuroinflammatory and autoimmune reactions in SCI, identifying changes in the expression of cytokines. Methods. In this pilot study, an extended multiplex analysis of the cytokine profiles in the serum of patients at 2 weeks post-SCI (n = 28) was carried out, together with an additional assessment of neuron-specific enolase (NSE) and vascular endothelial growth factor (VEGF) levels by enzyme-linked immunosorbent assay. A total of 16 uninjured subjects were enrolled as controls. Results. The data obtained showed a large elevation of IFNγ (>52 fold), CCL27 (>13 fold), and CCL26 (>8 fold) 2 weeks after SCI. The levels of cytokines CXCL5, CCL11, CXCL11, IL10, TNFα, and MIF were different between patients with basel	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU